Reference : Tanshinone IIA exhibits anticonvulsant activity in zebrafish and mouse seizure models
Scientific journals : Article
Human health sciences : Multidisciplinary, general & others
http://hdl.handle.net/10993/27293
Tanshinone IIA exhibits anticonvulsant activity in zebrafish and mouse seizure models
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Buenafe, O. E. [Laboratory for Molecular Biodiscovery, Department of Pharmaceutical and Pharmacological Sciences, KU Leuven - University of Leuven, 3000 Leuven, Belgium]
Orellana-Paucar, A. [Laboratory for Molecular Biodiscovery, Department of Pharmaceutical and Pharmacological Sciences, KU Leuven - University of Leuven, 3000 Leuven, Belgium, Facultad de Ciencias Quimicas, Escuela de Bioquimica y Farmacia, Universidad de Cuenca, Cuenca 101168, Ecuador]
Maes, J. [Laboratory for Molecular Biodiscovery, Department of Pharmaceutical and Pharmacological Sciences, KU Leuven - University of Leuven, 3000 Leuven, Belgium]
Huang, H. [College of Pharmacy, Gannan Medical University, Ganzhou 341000, China]
Ying, X. [College of Pharmacy, Nankai University, Tianjin 300071, China, Analysis Center, Tsinghua University, Beijing 100084, China]
De Borggraeve, W. [Molecular Design and Synthesis, Department of Chemistry, KU Leuven - University of Leuven, 3001 Leuven, Belgium]
Crawford, Alexander Dettmar mailto [University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB) >]
Luyten, W. [Department of Biology, KU Leuven - University of Leuven, 3000 Leuven, Belgium]
Esguerra, C. V. [Laboratory for Molecular Biodiscovery, Department of Pharmaceutical and Pharmacological Sciences, KU Leuven - University of Leuven, 3000 Leuven, Belgium]
De Witte, P. [Laboratory for Molecular Biodiscovery, Department of Pharmaceutical and Pharmacological Sciences, KU Leuven - University of Leuven, 3000 Leuven, Belgium]
2013
ACS Chemical Neuroscience
4
11
1479-1487
Yes (verified by ORBilu)
19487193
[en] Salvia miltiorrhiza ; Tanshinone IIA ; Alzheimer Disease ; Animals ; Anticonvulsants ; Brain Ischemia ; Disease Models, Animal ; Disease Progression ; Diterpenes, Abietane ; Drugs, Chinese Herbal ; Fertilization in Vitro ; Injections, Intraventricular ; Larva ; Male ; Medicine, Chinese Traditional ; Mice ; Microinjections ; Neuroprotective Agents ; Pentylenetetrazole ; Plant Extracts ; Plant Roots ; Proto-Oncogene Proteins c-fos ; Seizures ; Small Molecule Libraries ; Zebrafish
[en] Danshen or Chinese red sage (Salvia miltiorrhiza, Bunge) is used by traditional Chinese medicine (TCM) practitioners to treat neurological, cardiovascular, and cerebrovascular disorders and is included in some TCM formulations to control epileptic seizures. In this study, acetonic crude extracts of danshen inhibited pentylenetetrazol (PTZ)-induced seizure activity in zebrafish larvae. Subsequent zebrafish bioassay-guided fractionation of the extract resulted in the isolation of four major tanshinones, which suppressed PTZ-induced activity to varying degrees. One of the active tanshinones, tanshinone IIA, also reduced c-fos expression in the brains of PTZ-exposed zebrafish larvae. In rodent seizure models, tanshinone IIA showed anticonvulsive activity in the mouse 6-Hz psychomotor seizure test in a biphasic manner and modified seizure thresholds in a complex manner for the mouse i.v. PTZ seizure assay. Interestingly, tanshinone IIA is used as a prescription drug in China to address cerebral ischemia in patients. Here, we provide the first in vivo evidence demonstrating that tanshinone IIA has anticonvulsant properties as well. © 2013 American Chemical Society.
Luxembourg Centre for Systems Biomedicine (LCSB): Chemical Biology (Crawford Group)
http://hdl.handle.net/10993/27293
10.1021/cn400140e

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