Reference : Innate and adaptive effects of inflammasomes on T cell responses
Scientific journals : Article
Human health sciences : Immunology & infectious disease
http://hdl.handle.net/10993/27259
Innate and adaptive effects of inflammasomes on T cell responses
English
Dostert, Catherine mailto [University of Luxembourg > Faculty of Science, Technology and Communication (FSTC) > Life Science Research Unit]
Ludigs, Kristina [Department of Biochemistry, Chemin des Boveresses 155, 1066 Epalinges, Switzerland]
Guarda, Greta [Department of Biochemistry, Chemin des Boveresses 155, 1066 Epalinges, Switzerland]
2013
Current Opinion in Immunology
25
3
359-365
Yes (verified by ORBilu)
International
0952-7915
[en] CD8+ T lymphocyte ; CINCA syndrome ; T lymphocyte ; Th1 cell ; Th17 cell ; Adaptive Immunity ; Animals ; Caspase 1 ; Cytokines ; Humans ; Immunity, Innate ; Inflammasomes ; T-Lymphocytes
[en] Inflammasomes are protein complexes that form in response to pathogen-derived or host-derived stress signals. Their activation leads to the production of inflammatory cytokines and promotes a pyrogenic cell death process. The massive release of inflammatory mediators that follows inflammasome activation is a key event in alarming innate immune cells. Growing evidence also highlights the role of inflammasome-dependent cytokines in shaping the adaptive immune response, as exemplified by the capacity of IL-1β to support Th17 responses, or by the finding that IL-18 evokes antigen-independent IFN-γ secretion by memory CD8+ T cells. A deeper understanding of these mechanisms and on how to manipulate this powerful inflammatory system therefore represents an important step forward in the development of improved vaccine strategies. © 2013 Elsevier Ltd.
PP00P3_139094, SNSF, Swiss National Science Foundation
http://hdl.handle.net/10993/27259
10.1016/j.coi.2013.02.008

File(s) associated to this reference

Fulltext file(s):

FileCommentaryVersionSizeAccess
Open access
Innate and adaptive effects.pdfPublisher postprint748.69 kBView/Open

Bookmark and Share SFX Query

All documents in ORBilu are protected by a user license.