Reference : Urinary C-peptide: A useful tool for evaluating the endogenous insulin reserve in coh...
Scientific journals : Article
Human health sciences : Multidisciplinary, general & others
http://hdl.handle.net/10993/27244
Urinary C-peptide: A useful tool for evaluating the endogenous insulin reserve in cohort and longitudinal studies of diabetes in childhood
English
De Beaufort, Carine mailto [University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB) >]
Den Boer, N. C. [Department of Pediatrics, Sophia Children's Hospital, Rotterdam, Netherlands]
Bruining, G. J. [Department of Pediatrics, Sophia Children's Hospital, Rotterdam, Netherlands]
Eilers, G. A. M. [Department of Pediatrics, Sophia Children's Hospital, Rotterdam, Netherlands]
Van Strik, R. [Department of Pediatrics, Sophia Children's Hospital, Rotterdam, Netherlands]
Weterings, T. [Department of Pediatrics, Sophia Children's Hospital, Rotterdam, Netherlands]
1988
Annals of Clinical Biochemistry
25
5
552-559
Yes (verified by ORBilu)
00045632
[en] C-Peptide ; Child ; Cohort Studies ; Diabetes Mellitus, Insulin-Dependent ; Glucagon ; Glycosuria ; Human ; Insulin ; Ketone Bodies ; Longitudinal Studies
[en] Increasing research into the remission phase of type I diabetes mellitus stresses the importance of a non-traumatic and reliable method for the evaluation of endogenous insulin production. We compared 24-h urinary C-peptide excretion (UCE) with plasma C-peptide values before and after stimulation with 1 mg glucagon in 24 type I diabetic children. Fasting plasma C-peptide values and stimulated plasma C-peptide values showed a linear correlation with 24 h UCE. Mean plasma C-peptide levels correlated inversely with the exogenous insulin dose. A slightly better correlation was found between the exogenous insulin dose and 24 h UCE. Control data of 24 h UCE were obtained from healthy siblings. A linear correlation with ages was found up to 10 years of age above which UCE values seem to reach a plateau. This effect of age, as well as the frequency of sampling was taken into account in the derivation of 95% reference intervals for UCE. The measurement of 24 h UCE appears to be a useful parameter to assess endogenous insulin production in diabetic children, provided that age is taken into account.
http://hdl.handle.net/10993/27244

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