Reference : Decreased prevalence of atopic diseases in children with diabetes
Scientific journals : Article
Human health sciences : Multidisciplinary, general & others
http://hdl.handle.net/10993/27218
Decreased prevalence of atopic diseases in children with diabetes
English
De Beaufort, Carine mailto [University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB) > >]
2000
Journal of Pediatrics
Mosby
137
470-474
Yes (verified by ORBilu)
0022-3476
1097-6833
St Louis
MO
[en] atopic diseases ; children ; diabetes ; risk ; protection ; type 1
[en] OBJECTIVE:
To test the hypothesis that atopic diseases in early life are associated with a reduced risk (protection) for the development of type 1 diabetes in childhood.
STUDY DESIGN:
European centers (n = 8) with access to population-based type 1 diabetes registries (>90% degree of ascertainment) participated in a case control study focusing on early exposures and risk factors for type 1 diabetes. Altogether, data from 1028 members of a case group and 2744 members of a control group corresponding to 85.4% eligible members of the case group and 76.1% of the control group were analyzed. Information in this study was collected regarding atopic diseases (atopic eczema, allergic rhinoconjunctivitis, and asthma).
RESULTS:
Atopic disease and asthma particularly are associated with significant reductions in risk of childhood type 1 diabetes. The risk reduction associated with asthma was observed reasonably consistently among the 8 study centers, which represent a wide range of diabetes incidence. Risk reductions associated with all 3 expressions of atopy were particularly marked in children whose type 1 diabetes was diagnosed in the 10- to 14-year age group.
CONCLUSION:
These findings indicate that atopic conditions may be protective against the development of type 1 diabetes and are consistent with the immunologic concept of T(H)1 (type 1 diabetes) and T(H)2 (atopy) diseases being mutually exclusive.
Eurodiab Substudy 2 Study Group
http://hdl.handle.net/10993/27218

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