Reference : Sexual precocity after immigration from developing countries to Belgium: Evidence of ...
Scientific journals : Article
Human health sciences : Multidisciplinary, general & others
http://hdl.handle.net/10993/27209
Sexual precocity after immigration from developing countries to Belgium: Evidence of previous exposure to organochlorine pesticides
English
Krstevska-Konstantinova, M. [Division of Ambulatory Pediatrics, University of Liège, C.H.U. Sart Tilman, B-4000 Liege, Belgium]
Charlier, C. [Division of Ambulatory Pediatrics, University of Liège, C.H.U. Sart Tilman, B-4000 Liege, Belgium]
Craen, M. [Division of Ambulatory Pediatrics, University of Liège, C.H.U. Sart Tilman, B-4000 Liege, Belgium]
Du Caju, M. [Division of Ambulatory Pediatrics, University of Liège, C.H.U. Sart Tilman, B-4000 Liege, Belgium]
Heinrichs, C. [Division of Ambulatory Pediatrics, University of Liège, C.H.U. Sart Tilman, B-4000 Liege, Belgium]
De Beaufort, Carine mailto [University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB) >]
Plomteux, G. [Division of Ambulatory Pediatrics, University of Liège, C.H.U. Sart Tilman, B-4000 Liege, Belgium]
Bourguignon, J. P. [Division of Ambulatory Pediatrics, University of Liège, C.H.U. Sart Tilman, B-4000 Liege, Belgium]
Lynge, E. [Division of Ambulatory Pediatrics, University of Liège, C.H.U. Sart Tilman, B-4000 Liege, Belgium]
Kulin, H. [Division of Ambulatory Pediatrics, University of Liège, C.H.U. Sart Tilman, B-4000 Liege, Belgium]
Russo, J. [Division of Ambulatory Pediatrics, University of Liège, C.H.U. Sart Tilman, B-4000 Liege, Belgium]
Gray, E. [Division of Ambulatory Pediatrics, University of Liège, C.H.U. Sart Tilman, B-4000 Liege, Belgium]
Møller, H. [Division of Ambulatory Pediatrics, University of Liège, C.H.U. Sart Tilman, B-4000 Liege, Belgium]
Brock, J. [Division of Ambulatory Pediatrics, University of Liège, C.H.U. Sart Tilman, B-4000 Liege, Belgium]
Sharpe, R. [Division of Ambulatory Pediatrics, University of Liège, C.H.U. Sart Tilman, B-4000 Liege, Belgium]
Bjerregaard, P. [Division of Ambulatory Pediatrics, University of Liège, C.H.U. Sart Tilman, B-4000 Liege, Belgium]
Vom Saal, F. [Division of Ambulatory Pediatrics, University of Liège, C.H.U. Sart Tilman, B-4000 Liege, Belgium]
2001
Human Reproduction
Oxford University Press
16
103
1020-1026
Yes (verified by ORBilu)
0268-1161
1460-2350
Oxford
United Kingdom
[en] Adopted children ; Organochlorine pesticides ; Precocious puberty ; Belgium
[en] In a retrospective auxological study of 145 patients seen in Belgium during a 9-year period for treatment of precocious puberty, 28% appeared to be foreign children (39 girls, one boy) who immigrated 4 to 5 years earlier from 22 developing countries, without any link to a particular ethnic or country background. The patients were either adopted (n = 28) or non-adopted (n = 12), the latter having normal weight and height at immigration and starting early puberty without evidence of earlier deprivation. This led to the hypothesis that the mechanism of precocious puberty might involve previous exposure to oestrogenic endocrine disrupters. A toxicological plasma screening for eight pesticides detected p,p′-DDE, which is derived from the organochlorine pesticide DDT. Median p,p′-DDE concentrations were respectively 1.20 and 1.04 ng/ml in foreign adopted (n = 15) and non-adopted (n = 11) girls with precocious puberty, while 13 out of 15 Belgian native girls with idiopathic or organic precocious puberty showed undetectable concentrations (<0.1 ng/ml). A possible relationship between transient exposure to endocrine disrupters and sexual precocity is suggested, and deserves further studies in immigrant children with non-advanced puberty.
http://hdl.handle.net/10993/27209

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