Reference : Insulin sensitivity modulates the growth response during the first year of high-dose ...
Scientific journals : Article
Human health sciences : Multidisciplinary, general & others
http://hdl.handle.net/10993/27175
Insulin sensitivity modulates the growth response during the first year of high-dose growth hormone treatment in short prepubertal children born small for gestational age
English
Gies, I. []
Thomas, M. []
Tenoutasse, S. []
De Waele, K. []
Lebrethon, M.C. []
Beckers, D. []
Francois, I. []
Maes, M. []
Rooman, R. []
De Beaufort, Carine mailto [University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB) > >]
Massa, G. []
De Schepper, J. []
2012
Hormone Research in Paediatrics
Karger
78
1
24-30
Yes
1663-2818
1663-2826
Basel
Switzerland
[en] insulin sensitivity ; Growth Hormone ; treatment ; small children ; SGA ; gestational age
[en] AIM:
To study the relationship between insulin sensitivity and growth response in short children born small for gestational age (SGA) treated with growth hormone (GH).
METHODS:
Randomized, open-label, 24-month intervention study in 40 short prepubertal SGA children [age (mean ± SD) 5.3 ± 1.5 years], who either remained untreated (n = 20) or were treated with GH (66 µg/kg/day; n = 20). Changes in fasting glucose, insulin, quantitative insulin sensitivity check index (QUICKI), IGF-1 and leptin after 1 and 2 years were studied.
RESULTS:
Mean height SDS increased from -3.3 ± 0.7 to -2.3 ± 0.7 after 1 year, and to -1.9 ± 0.7 after 2 years of treatment. QUICKI decreased significantly (p = 0.008) in the first year of GH treatment and stabilized in the second year. Baseline QUICKI was positively associated (r = 0.40; p < 0.05) with the change in height SDS in the first year.
CONCLUSION:
Higher insulin sensitivity at the start of GH therapy is associated with greater first-year growth response to GH, and could be a promising parameter in selecting prepubertal short SGA children for GH treatment. However, this finding needs to be confirmed in larger studies.
http://hdl.handle.net/10993/27175
10.1159/000339829

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