Reference : The genetic and regulatory architecture of ERBB3-type 1 diabetes susceptibility locus
Scientific journals : Article
Human health sciences : Multidisciplinary, general & others
http://hdl.handle.net/10993/27173
The genetic and regulatory architecture of ERBB3-type 1 diabetes susceptibility locus
English
Kaur, S. [Copenhagen Diabetes Research Center (CPH-DIRECT), Department of Pediatrics, Herlev University Hospital, Herlev Ringvej 75, Herlev, Denmark, Faculty of Health and Medical Sciences, University of Copenhagen, Denmark]
Mirza, A. H. [Copenhagen Diabetes Research Center (CPH-DIRECT), Department of Pediatrics, Herlev University Hospital, Herlev Ringvej 75, Herlev, Denmark, Faculty of Health and Medical Sciences, University of Copenhagen, Denmark, Center for Non-coding RNA in Technology and Health, University of Copenhagen, Denmark]
Brorsson, C. A. [Copenhagen Diabetes Research Center (CPH-DIRECT), Department of Pediatrics, Herlev University Hospital, Herlev Ringvej 75, Herlev, Denmark]
Fløyel, T. [Copenhagen Diabetes Research Center (CPH-DIRECT), Department of Pediatrics, Herlev University Hospital, Herlev Ringvej 75, Herlev, Denmark]
Størling, J. [Copenhagen Diabetes Research Center (CPH-DIRECT), Department of Pediatrics, Herlev University Hospital, Herlev Ringvej 75, Herlev, Denmark]
Mortensen, H. B. [Copenhagen Diabetes Research Center (CPH-DIRECT), Department of Pediatrics, Herlev University Hospital, Herlev Ringvej 75, Herlev, Denmark, Faculty of Health and Medical Sciences, University of Copenhagen, Denmark]
Pociot, F. [Copenhagen Diabetes Research Center (CPH-DIRECT), Department of Pediatrics, Herlev University Hospital, Herlev Ringvej 75, Herlev, Denmark, Faculty of Health and Medical Sciences, University of Copenhagen, Denmark, Center for Non-coding RNA in Technology and Health, University of Copenhagen, Denmark]
Aanstoot, H.-J. [Center for Pediatric and Adolescent Diabetes Care and Research, Rotterdam, Netherlands]
De Beaufort, Carine mailto [University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB) >]
Cameron, F. [Department of Endocrinology and Diabetes, Royal Children's Hospital, Parkville, VIC, Australia]
Castano, L. [Endocrinology and Diabetes Research Group, Hospital de Cruces, University of Basque Country, Barakaldo, Spain]
Dorchy, H. [Diabetology Clinic, University Hospital Reine Fabiola, Brussels, Belgium]
Fisher, L. [Department of Endocrinology and Diabetes Children's Hospital of Los Angeles, Los Angeles, CA, United States]
Kaprio, E. [Department of Paediatrics, Peijas Hospital, HUS, Finland]
Lange, K. [Department of Medical Psychology, Hannover Medical School, Hannover, Germany]
Neu, A. [Clinic for Children and Adolescence, University of Tuebingen, Tuebingen, Germany]
Njolstad, P. R. [Department of Clinical Medicine University of Bergen, Bergen, Norway, Department of Paediatrics, Haukeland University Hospital, Bergen, Norway]
Phillip, M. [National Center of Childhood Diabetes, Schneiders Medical Center of Israel, Petah Tikva, Israel]
Urukami, T. [School of Medicine, Nihon University, Tokyo, Japan]
Barrett, T. [Institute of Child Health and Birmingham Children's Hospital, University of Birmingham, Birmingham, United Kingdom]
Chiarelli, F. [Clinica Pediatrica, Ospedale Policlinico, Chieti, Italy]
Danne, T. [Kinderkrankenhaus auf der Bult, Hannover, Germany]
Hoey, H. [University of Dublin, National Children's Hospital, Tallaght, Ireland]
Kocova, M. [Pediatric Clinic-Skopje, Macedonia]
Mortensen, B. [Department of Pediatrics, Herlev Hospital and Faculty of Health and Medical Sciences, University of Copenhagen, Denmark]
Schoenle, J. [University Children's Hospital, Zurich, Switzerland]
Swift, G. F. [Leicester Royal Infirmary Childrens Hospital, Leicester, United Kingdom]
Vanelli, M. [Clinica Pediatrica, Centro di Diabetologia, Parma, Italy]
Åman, J. [Örebro Medical Centre Hospital, Department of Paediatrics, Sweden]
Robert, J.J. []
2016
Molecular and Cellular Endocrinology
Elsevier Ireland Ltd
419
83-91
Yes (verified by ORBilu)
03037207
[en] Apoptosis ; Beta cell ; CTCF ; ERBB3 ; LncRNAs ; Type 1 diabetes ; Article ; B lymphocyte ; ERBB3 gene
[en] The study aimed to explore the role of ERBB3 in type 1 diabetes (T1D). We examined whether genetic variation of ERBB3 (rs2292239) affects residual β-cell function in T1D cases. Furthermore, we examined the expression of ERBB3 in human islets, the effect of ERBB3 knockdown on apoptosis in insulin-producing INS-1E cells and the genetic and regulatory architecture of the ERBB3 locus to provide insights to how rs2292239 may confer disease susceptibility. rs2292239 strongly correlated with residual β-cell function and metabolic control in children with T1D. ERBB3 locus associated lncRNA (NONHSAG011351) was found to be expressed in human islets. ERBB3 was expressed and down-regulated by pro-inflammatory cytokines in human islets and INS-1E cells; knockdown of ERBB3 in INS-1E cells decreased basal and cytokine-induced apoptosis. Our data suggests an important functional role of ERBB3 and its potential regulators in the β-cells and may constitute novel targets to prevent β-cell destruction in T1D. © 2015 Elsevier Ireland Ltd.
http://hdl.handle.net/10993/27173
10.1016/j.mce.2015.10.002

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