Reference : Computational methods for the design of effective therapies against drug resistant HI...
Scientific journals : Article
Life sciences : Multidisciplinary, general & others
http://hdl.handle.net/10993/26994
Computational methods for the design of effective therapies against drug resistant HIV strains
English
Beerenwinkel, N. [> >]
Sing, T. [> >]
Lengauer, T. [> >]
Rahnenführer []
Roomp, Kirsten mailto [University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB) > >]
Savenkov, I. [> >]
Fischer, R. [> >]
Hoffmann, D. [> >]
Selbig, J. [> >]
Korn, K. [> >]
Walter, H. [> >]
Berg, T. [> >]
Braun, P. [> >]
Fätkenheuer []
Oette, M. [> >]
Rockstroh, J. [> >]
Kupfer, B. [> >]
Kaiser, R. [> >]
Däumer []
2005
Bioinformatics
Oxford University Press - Journals Department
21
21
3943-50
Yes (verified by ORBilu)
1367-4803
1460-2059
Oxford
United Kingdom
[en] Viral Vaccines/ administration & dosage/ genetics ; Databases, Factual ; Drug Design ; Drug Information Services ; Drug Resistance, Viral/drug effects/genetics ; Drug Therapy, Computer-Assisted/ methods ; Gene Therapy ; HIV Infections/ drug therapy ; Humans ; Database Management Systems
[en] Summary: The development of drug resistance is a major obstacle to successful treatment of HIV infection. The extraordinary replication dynamics of HIV facilitates its escape from selective pressure exerted by the human immune system and by combination drug therapy. We
have developed several computational methods whose combined use can support the design of optimal antiretroviral therapies based on viral genomic data.
http://hdl.handle.net/10993/26994
10.1093/bioinformatics/bti654

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