Reference : Interbirth Interval Is Associated With Childhood Type 1 Diabetes Risk
Scientific journals : Article
Human health sciences : Multidisciplinary, general & others
http://hdl.handle.net/10993/26983
Interbirth Interval Is Associated With Childhood Type 1 Diabetes Risk
English
Cardwell, C.R. []
Svensson, J. []
Waldhoer, T. []
Ludvigsson, J. []
Sadauskaite-Kuehne, V. []
Roberts, C.L. []
Parslow, R.C. []
Wadsworth, E.J. []
Brigis, G. []
Urbonaite, B. []
Schober, E. []
Devoti, G. []
Ionescu-Tirgoviste, C. []
De Beaufort, Carine mailto [University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB) > >]
Soltesz, G. []
Patterson, C.C. []
2012
Diabetes
American Diabetes Association
61
3
702-707
Yes (verified by ORBilu)
0012-1797
1939-327X
Alexandria
VA
[en] medical and health sciences ; Medicin Och Hälsovetenskap ; medicine
[en] Short interbirth interval has been associated with maternal complications and childhood autism and leukemia, possibly due to deficiencies in maternal micronutrients at conception or increased exposure to sibling infections. A possible association between interbirth interval and subsequent risk of childhood type 1 diabetes has not been investigated. A secondary analysis of 14 published observational studies of perinatal risk factors for type 1 diabetes was conducted. Risk estimates of diabetes by category of interbirth interval were calculated for each study. Random effects models were used to calculate pooled odds ratios (ORs) and investigate heterogeneity between studies. Overall, 2,787 children with type 1 diabetes were included. There was a reduction in the risk of childhood type 1 diabetes in children born to mothers after interbirth intervals andlt;3 years compared with longer interbirth intervals (OR 0.82 [95% CI 0.72-0.93]). Adjustments for various potential confounders little altered this estimate. In conclusion, there was evidence of a 20% reduction in the risk of childhood diabetes in children born to mothers after interbirth intervals andlt;3 years.
http://hdl.handle.net/10993/26983

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