Reference : A draft network of ligand–receptor-mediated multicellular signalling in human
Scientific journals : Article
Life sciences : Multidisciplinary, general & others
http://hdl.handle.net/10993/26856
A draft network of ligand–receptor-mediated multicellular signalling in human
English
Ramilowski, Jordan [RIKEN Center for Life Science Technologies > Division of Genomic Technologies]
Goldberg, Tatyana [Technische Universität München (TUM) > Department for Bioinformatics and Computational Biology-I12 > > ; Center of Doctoral Studies in Informatics and its Application (CeDoSIA) > TUM Graduate School]
Harshbarger, Jayson [RIKEN Center for Life Science Technologies > Division of Genomic Technologies]
Kloppman, Edda [Technische Universität München (TUM) > Department for Bioinformatics and Computational Biology-I12]
Lizio, Marina [RIKEN Center for Life Science Technologies > Division of Genomic Technologies]
Satagopam, Venkata mailto [University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB) > >]
Itoh, Masayoshi [RIKEN Center for Life Science Technologies > Division of Genomic Technologies > > ; RIKEN Preventive Medicine and Diagnosis Innovation Program]
Kawaji, Hideya [RIKEN Preventive Medicine and Diagnosis Innovation Program > > > ; RIKEN Center for Life Science Technologies > Division of Genomic Technologies]
Carninci [RIKEN Center for Life Science Technologies > Division of Genomic Technologies]
Rost, Burkhard [Technische Universität München (TUM) > Department for Bioinformatics and Computational Biology-I12 > > ; TUM Graduate School > Center of Doctoral Stuadies in Informatics and its Application (CeDoSIA)]
Forrest, Alistair [RIKEN Center for Life Science Technologies > Division of Genomic Technologies > > ; Harry Perkins Institute of Medical Research > QEII Medical Centre and Centre for Medical Research, the University of Western Australia]
22-Jul-2015
Nature Communications
Nature Pub.lishing Group
6
Yes (verified by ORBilu)
2041-1723
London
United Kingdom
[en] Cell-to-cell communication across multiple cell types and tissues strictly governs proper
functioning of metazoans and extensively relies on interactions between secreted ligands
and cell-surface receptors. Herein, we present the first large-scale map of cell-to-cell
communication between 144 human primary cell types. We reveal that most cells express
tens to hundreds of ligands and receptors to create a highly connected signalling network
through multiple ligand–receptor paths. We also observe extensive autocrine signalling with
approximately two-thirds of partners possibly interacting on the same cell type. We find that
plasma membrane and secreted proteins have the highest cell-type specificity, they are
evolutionarily younger than intracellular proteins, and that most receptors had evolved before
their ligands. We provide an online tool to interactively query and visualize our networks and
demonstrate how this tool can reveal novel cell-to-cell interactions with the prediction that
mast cells signal to monoblastic lineages via the CSF1–CSF1R interacting pair.
Luxembourg Centre for Systems Biomedicine (LCSB): Bioinformatics Core (R. Schneider Group)
http://hdl.handle.net/10993/26856
10.1038/ncomms8866

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