Reference : Dissipation in noisy chemical networks: The role of deficiency
Scientific journals : Article
Physical, chemical, mathematical & earth Sciences : Physics
http://hdl.handle.net/10993/26845
Dissipation in noisy chemical networks: The role of deficiency
English
Esposito, Massimiliano mailto [University of Luxembourg > Faculty of Science, Technology and Communication (FSTC) > Physics and Materials Science Research Unit >]
Polettini, Matteo mailto [University of Luxembourg > Faculty of Science, Technology and Communication (FSTC) > Physics and Materials Science Research Unit >]
Wachtel, Artur mailto [University of Luxembourg > Faculty of Science, Technology and Communication (FSTC) > Physics and Materials Science Research Unit >]
2015
Journal of Chemical Physics
American Institute of Physics
145
18
184103
Yes (verified by ORBilu)
International
0021-9606
1089-7690
New York
NY
[en] biochemichal networks ; single-cell ; thermodynamics
[en] We study the effect of intrinsic noise on the thermodynamic balance of complex chemical networks subtending cellular metabolism and gene regulation. A topological network property called deficiency, known to determine the possibility of complex behavior such as multistability and oscillations, is shown to also characterize the entropic balance. In particular, when deficiency is zero the average stochastic dissipation rate equals that of the corresponding deterministic model, where correlations are disregarded. In fact, dissipation can be reduced by the effect of noise, as occurs in a toy model of metabolism that we employ to illustrate our findings. This phenomenon highlights that there is a close interplay between deficiency and the activation of new dissipative pathways at low molecule numbers
http://hdl.handle.net/10993/26845
10.1063/1.4935064

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