Reference : Molecular basis for skeletal variation: insights from developmental genetic studies i...
Scientific journals : Article
Life sciences : Genetics & genetic processes
http://hdl.handle.net/10993/2684
Molecular basis for skeletal variation: insights from developmental genetic studies in mice.
English
Kappen, C. [> >]
Neubuser, A. [> >]
Balling, Rudi mailto []
Finnell, R. [> >]
2007
Birth Defects Research. Part B, Developmental and Reproductive Toxicology
80
6
425-50
Yes (verified by ORBilu)
1542-9733
1542-9741
United States
[en] Abnormalities, Drug-Induced/genetics ; Animals ; Bone Development/drug effects/genetics ; Bone and Bones/abnormalities ; Gene Expression Regulation, Developmental/physiology ; Mice ; Teratogens/toxicity
[en] Skeletal variations are common in humans, and potentially are caused by genetic as well as environmental factors. We here review molecular principles in skeletal development to develop a knowledge base of possible alterations that could explain variations in skeletal element number, shape or size. Environmental agents that induce variations, such as teratogens, likely interact with the molecular pathways that regulate skeletal development.
http://hdl.handle.net/10993/2684
10.1002/bdrb.20136
(c) 2007 Wiley-Liss, Inc.

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