Reference : Neurological Diseases from a Systems Medicine Point of View.
Scientific journals : Article
Human health sciences : Multidisciplinary, general & others
http://hdl.handle.net/10993/26771
Neurological Diseases from a Systems Medicine Point of View.
English
Ostaszewski, Marek mailto [University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB) >]
Skupin, Alexander mailto [University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB) >]
Balling, Rudi mailto [University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB) >]
2016
Methods in molecular biology (Clifton, N.J.)
1386
221-50
Yes (verified by ORBilu)
1064-3745
1940-6029
United States
[en] Cellular networks ; Connectome ; Cross-scale analysis ; Epilepsies ; Molecular networks ; Multiscale brain networks ; Network reconstruction ; Neurodegenerative diseases ; Systems medicine
[en] The difficulty to understand, diagnose, and treat neurological disorders stems from the great complexity of the central nervous system on different levels of physiological granularity. The individual components, their interactions, and dynamics involved in brain development and function can be represented as molecular, cellular, or functional networks, where diseases are perturbations of networks. These networks can become a useful research tool in investigating neurological disorders if they are properly tailored to reflect corresponding mechanisms. Here, we review approaches to construct networks specific for neurological disorders describing disease-related pathology on different scales: the molecular, cellular, and brain level. We also briefly discuss cross-scale network analysis as a necessary integrator of these scales.
Luxembourg Centre for Systems Biomedicine (LCSB): Experimental Neurobiology (Balling Group) ; Luxembourg Centre for Systems Biomedicine (LCSB): Integrative Cell Signalling (Skupin Group)
http://hdl.handle.net/10993/26771
10.1007/978-1-4939-3283-2_11

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