Reference : Critical Points in Tumorigenesis: A Carcinogen-Initiated Phase Transition Analyzed vi...
Scientific journals : Article
Life sciences : Biotechnology
Systems Biomedicine
http://hdl.handle.net/10993/26724
Critical Points in Tumorigenesis: A Carcinogen-Initiated Phase Transition Analyzed via Single-Cell Proteomics.
English
Poovathingal, Suresh Kumar mailto [University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB) >]
Kravchenko-Balasha, Nataly [> >]
Shin, Young Shik [> >]
Levine, Raphael David [> >]
Heath, James R. [> >]
2016
Small (Weinheim an der Bergstrasse, Germany)
12
11
1425-31
Yes (verified by ORBilu)
1613-6810
1613-6829
Germany
[en] carcinogenesis ; microfluidics ; phase transition ; single-cell proteomics ; steady state
[en] A kinetic, single-cell proteomic study of chemically induced carcinogenesis is interpreted by treating the single-cell data as fluctuations of an open system transitioning between different steady states. In analogy to a first-order transition, phase coexistence and the loss of degrees of freedom are observed. The transition is detected well before the appearance of the traditional biomarker of the carcinogenic transformation.
http://hdl.handle.net/10993/26724
10.1002/smll.201501178
(c) 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

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