Reference : Impulse parametric sensitivity analysis
Scientific congresses, symposiums and conference proceedings : Unpublished conference
Engineering, computing & technology : Multidisciplinary, general & others
http://hdl.handle.net/10993/26599
Impulse parametric sensitivity analysis
English
Perumal, Thanneer Malai [National University of Singapore > Chemical and Biomolecular Engineering]
Gunawan, R. [> >]
2011
9686-9690
Complexity often limits human intuition in understanding system behavior, motivating the creation and analysis of mathematical models to understand these systems. One of the most commonly used analyses is the classical parametric sensitivity analysis (PSA), which maps out the parametric dependence of system behavior. In this article, we present a novel sensitivity analysis, called impulseparametric sensitivity analyses (iPSA), which is based on impulse perturbations to model parameters. Hence, the iPSA gives a step-by-step mechanistic insight on how a particular output behavior is accomplished and complementarily how (an impulse) perturbation propagates through the network. More specifically iPSA coefficients can reveal which parameters are essential and when they become important. The efficacy of this analysis is demonstrated on examples drawn from biology: the Fas-induced cell death model of human Jurkat T-cells.
Yes
No
International
18th IFAC World Congress
28-08-2011 to 2-09-2011
IFAC
Milan
Italy
[en] Sensitivity Analysis ; Robustness ; Model ; Systems Biology
http://hdl.handle.net/10993/26599
10.3182/20110828-6-IT-1002.03771

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