Reference : Dual bioactivity of resveratrol fatty alcohols: differentiation of neural stem cells ...
Scientific journals : Article
Life sciences : Multidisciplinary, general & others
http://hdl.handle.net/10993/26597
Dual bioactivity of resveratrol fatty alcohols: differentiation of neural stem cells and modulation of neuroinflammation
English
Hauss, Frederique [> >]
Liu, Jiawei [> >]
Michelucci, Alessandro [University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB) > >]
Coowar, Djalil [> >]
Morga, Eleonora mailto [University of Luxembourg > Faculty of Science, Technology and Communication (FSTC) > Life Science Research Unit >]
Heuschling, Paul mailto [University of Luxembourg > Faculty of Science, Technology and Communication (FSTC) > Life Science Research Unit]
Luu, Bang [> >]
2007
Bioorganic & Medicinal Chemistry Letters
Elsevier Science
17
15
4218-4222
Yes (verified by ORBilu)
0960-894X
1464-3405
Oxford
United Kingdom
[en] Resveratrol fatty alcohols ; Neuroinflammation ; Neural stem cells ; Microglia ; Neurodegenerative diseases
[en] The synthesis of resveratrol fatty alcohols (RFAs), a new class of small molecules presenting strong potential for the treatment of neurological diseases, is described. RFAs, hybrid compounds combining the resveratrol nucleus and omega-alkanol side chains, are able to modulate neuroinflammation and to induce differentiation of neural stem cells into mature neurons. Acting on neuroprotection and neuroregeneration, RFAs represent an innovative approach for the treatment or cure of neuropathies.
http://hdl.handle.net/10993/26597
10.1016/j.bmcl.2007.05.037

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