Reference : Discriminative power of different nonmotor signs in early Parkinson's disease. A case...
Scientific journals : Article
Life sciences : Multidisciplinary, general & others
http://hdl.handle.net/10993/26587
Discriminative power of different nonmotor signs in early Parkinson's disease. A case-control study
English
Diederich, Nico [University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB) > >]
Pieri, Vannina [> >]
Hipp, Geraldine [> >]
Rufra, Olivier [> >]
Blyth, Sara [> >]
Vaillant, Michel [> >]
2010
Movement Disorders : Official Journal of the Movement Disorder Society
Wiley Liss, Inc.
25
7
882-887
Yes (verified by ORBilu)
0885-3185
1531-8257
New York
NY
[en] The objective of this study was to evaluate the discriminative power of different nonmotor signs for early diagnosis of Parkinson's disease (PD). Thirty patients with PD with <or=3 years of disease duration were compared with 30 healthy controls. Six deficit domains (DD) were defined: hyposmia, sleep abnormalities, dysautonomia, visual deficits, executive dysfunction, and depression. Plotting of Receiver operating characteristic (ROC) curves and exact conditional logistic modeling, followed by manual stepwise descending procedure were used to identify a model for nonmotor signs that detects early PD. Patients with PD and controls did not differ in terms of age, gender, and educational level. Several DD discriminated patients with PD from healthy controls. Visual deficits showed the largest area under the ROC curve (0.83), followed by hyposmia (0.81) and dysautonomia (0.80). When combining the DD visual deficits and dysautonomia, the best residual model was obtained; it maximized both sensitivity and specificity for PD at a level of 0.77. At an early disease stage, several nonmotor domains were already able to discriminate patients with PD from healthy controls. Visual deficits had the best discriminatory power. Being brief and inexpensive, visual tests should be further investigated in larger cohorts as potential screening tool for early PD.
http://hdl.handle.net/10993/26587
10.1002/mds.22963

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