Reference : Nuclear calcium signaling in spinal neurons drives a genomic program required for per...
Scientific journals : Article
Life sciences : Multidisciplinary, general & others
http://hdl.handle.net/10993/26568
Nuclear calcium signaling in spinal neurons drives a genomic program required for persistent inflammatory pain
English
Simonetti, Manuela [University of Heidelberg > Institute for Pharmacology]
Hagenston, Anna [Interdisciplinary Center for Neurosciences, University of Heidelberg > Department of Neurobiology]
Vardeh, Daniel [University of Heidelberg > Institute for Pharmacology]
Freitag, Eckehard [Interdisciplinary Center for Neurosciences, University of Heidelberg > Department of Neurobiology]
Mauceri, Daniela [Interdisciplinary Center for Neurosciences, University of Heidelberg > Department of Neurobiology]
Lu, Jianning [University of Heidelberg > Institute for Pharmacology]
Satagopam, Venkata mailto [University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB) > >]
Schneider, Reinhard mailto [University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB) > > ; European Molecular Biology Laboratory (EMBL) > 3Structural and Computational Biology Unit]
Costigan, Michael [Children’s Hospital Boston and Harvard Medical School > F.M. Kirby Neurobiology Center]
Bading, Hilmar [Interdisciplinary Center for Neurosciences, University of Heidelberg > Department of Neurobiology]
Kuner, Rohini [University of Heidelberg > Institute for Pharmacology]
2013
Neuron
Cell Press
77
1
43-57
Yes (verified by ORBilu)
0896-6273
1097-4199
Cambridge
United Kingdom
[en] Persistent pain induced by noxious stimuli is characterized by the transition from normosensitivity to hypersensitivity. Underlying mechanisms are not well understood, although gene expression is considered important. Here we show that persistent nociceptive-like activity triggers calcium transients in neuronal nuclei within the superficial spinal dorsal horn, and that nuclear calcium is necessary for the development of long-term inflammatory hypersensitivity. Using a nucleusspecific calcium signal perturbation strategy in vivo complemented by gene profiling, bioinformatics and functional analyses, we discovered a pain-associated, nuclear calciumregulated gene program in spinal excitatory neurons. This includes C1q, a novel modulator of synaptic spine morphogenesis, which we found to contribute to activity-dependent spine remodelling on spinal neurons in a manner functionally associated with inflammatory
hypersensitivity. Thus, nuclear calcium integrates synapse-to-nucleus communication following
noxious stimulation and controls a spinal genomic response that mediates the transition between
acute and long-term nociceptive sensitization by modulating functional and structural plasticity.
Luxembourg Centre for Systems Biomedicine (LCSB): Bioinformatics Core (R. Schneider Group)
http://hdl.handle.net/10993/26568
10.1016/j.neuron.2012.10.037.

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