Reference : Lack of Polysomnographic Non-REM Sleep Changes in Early Parkinson’s Disease
Scientific journals : Article
Life sciences : Multidisciplinary, general & others
http://hdl.handle.net/10993/26500
Lack of Polysomnographic Non-REM Sleep Changes in Early Parkinson’s Disease
English
Diederich, Nico [University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB) > > ; Centre Hospitalier de Luxembourg > Department of Neuroscience > > ; Centre Hospitalier de Luxembourg > Interdisciplinary Sleep Laboratory]
Rufra, Olivier [Centre Hospitalier de Luxembourg > Interdisciplinary Sleep Laboratory]
Pieri, Vannina [Centre Hospitalier de Luxembourg > Department of Neuroscience]
Hipp, Géraldine [Centre Hospitalier de Luxembourg > Department of Neuroscience]
Vaillant, Michel [CRP-Santé > Methodology and Statistical Unit]
2013
Movement Disorders : Official Journal of the Movement Disorder Society
Wiley Liss, Inc.
Yes (verified by ORBilu)
0885-3185
1531-8257
New York
NY
[en] Parkinson’s disease ; polysomnography ; REM sleep behavior disorder ; sleep ; sleep questionnaire
[en] Background: Polysomnography (PSG) data are rare in patients who have early stage idiopathic Parkinson’s disease (IPD).
Methods: Thirty-three patients who had IPD with a disease duration 3 years and 37 age-matched controls were recruited. PSG analysis was performed on current
medication.
Results: Patients with IPD had a reduced mean percentage of muscle atonia during rapid eye movement (REM) sleep (80% vs 93%; P < 0.05). Total sleep time, sleep efficiency, indices/hour of arousals, awakenings, apnea/hypopnea, and periodic leg movements were similar in both groups. Age, but not dopaminergic medication, had a negative impact on sleep architecture in patients with IPD. There was no correlation between sleep efficiency assessed by PSG and sleep quality assessed by questionnaire.
Conclusions: The results confirmed a reduction in muscle atonia during REM sleep as a characteristic finding in early IPD. However, there were no further disease-inherent
or medication-induced changes in sleep architecture. Although sleep disturbances are considered to be an integral part of IPD, PSG cannot yet identify them objectively at an early stage. VC 2013 International Parkinson and Movement Disorder Society
Luxembourg Centre for Systems Biomedicine (LCSB): Experimental Neurobiology (Balling Group)
http://hdl.handle.net/10993/26500
10.1002/mds.25520

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