Reference : Analysis of biochemical networks using linear programming
Scientific congresses, symposiums and conference proceedings : Paper published in a book
Engineering, computing & technology : Multidisciplinary, general & others
http://hdl.handle.net/10993/2582
Analysis of biochemical networks using linear programming
English
Simeonidis, Vangelis mailto [University College London - UCL > Chemical Engineering]
Dartnell, Lewis []
Bogle, I. David L. []
Papageorgiou, Lazaros G. []
Dec-2005
Proceedings of the 7th World Congress of Chemical Engineering on CD-ROM
Institution of Chemical Engineers (IChemE)
Yes
No
International
9780852954942
7th World Congress of Chemical Engineering
10-14 July 2005
Institution of Chemical Engineers (IChemE)
Glasgow
Scotland, UK
[en] linear programming ; shortest path algorithm ; pathway distance ; metabolic pathways ; genome distance ; p53 cell cycle and apoptosis control network ; network robustness ; tumour inducing viruses
[en] The application of mathematical programming methodologies to biochemical systems is demonstrated with the presentation of a linear programming (LP) algorithm for calculating minimal pathway distances in biochemical networks. Minimal pathway distances are identified as the smallest number of steps separating two nodes in the network. Two case studies are examined: 1) the minimal distances for Escherichia coli Small Molecule Metabolism (SMM) enzymes are calculated and their correlations with genome distance and enzyme function are considered; 2) a study of the p53 cell cycle and apoptosis control network is performed in order to assess the survivability of the network to both random node failures and a directed assault, by studying the modification of the network’s diameter for successive protein knockouts. The results verify the applicability of the algorithm to problems of biochemical nature.
Researchers ; Professionals
http://hdl.handle.net/10993/2582
http://www.icheme.org/shop/books/7th%20world%20congress%20of%20chemical%20engineering.aspx

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