Reference : A constraint-based modelling approach to metabolic dysfunction in Parkinson's disease
Scientific journals : Article
Human health sciences : Multidisciplinary, general & others
http://hdl.handle.net/10993/24344
A constraint-based modelling approach to metabolic dysfunction in Parkinson's disease
English
Mao, Longfei mailto [University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB) >]
Nicolae, Averina mailto [University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB) >]
Oliveira, Miguel mailto [University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB) >]
He, Feng [Luxembourg Institute of Health (LIH) > Department of Infection and Immunity]
Hachi, Siham mailto [University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB) >]
Fleming, Ronan MT mailto [University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB) >]
2015
Computational and Structural Biotechnology Journal
Elsevier
13
484 - 491
Yes (verified by ORBilu)
International
2001-0370
[en] Dopaminergic neurons ; Constraint-based modelling ; Metabolic reconstruction ; Energy metabolism ; Parkinson's disease
[en] Abstract One of the hallmarks of sporadic Parkinson's disease is degeneration of dopaminergic neurons in the pars compacta of the substantia nigra. The aetiopathogenesis of this degeneration is still not fully understood, with dysfunction of many biochemical pathways in different subsystems suggested to be involved. Recent advances in constraint-based modelling approaches hold great potential to systematically examine the relative contribution of dysfunction in disparate pathways to dopaminergic neuronal degeneration, but few studies have employed these methods in Parkinson's disease research. Therefore, this review outlines a framework for future constraint-based modelling of dopaminergic neuronal metabolism to decipher the multi-factorial mechanisms underlying the neuronal pathology of Parkinson's disease.
Luxembourg Centre for Systems Biomedicine (LCSB): Systems Biochemistry (Fleming Group) ; Luxembourg Centre for Systems Biomedicine (LCSB): Experimental Neurobiology (Balling Group)
http://hdl.handle.net/10993/24344
10.1016/j.csbj.2015.08.002
http://www.sciencedirect.com/science/article/pii/S2001037015000379

File(s) associated to this reference

Fulltext file(s):

FileCommentaryVersionSizeAccess
Open access
main.pdfPublisher postprint1.15 MBView/Open

Bookmark and Share SFX Query

All documents in ORBilu are protected by a user license.