Reference : The Parkinson's Disease Map: A Framework for Integration, Curation and Exploration of...
Scientific congresses, symposiums and conference proceedings : Poster
Life sciences : Multidisciplinary, general & others
http://hdl.handle.net/10993/2261
The Parkinson's Disease Map: A Framework for Integration, Curation and Exploration of Disease-related Pathways
English
Ostaszewski, Marek mailto [University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB) > >]
Fujita, Kazuhiro mailto [The Systems Biology Institute (SBI) - Japan]
Matsuoka, Yukiko mailto [The Systems Biology Institute (SBI) - Japan]
Ghosh, Samik mailto [The Systems Biology Institute (SBI) - Japan]
Glaab, Enrico mailto [University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB) > >]
Trefois, Christophe mailto [University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB) > >]
Crespo, Isaac mailto [University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB) > >]
Perumal, Thanneer Malai mailto [University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB) > >]
Jurkowski, Wiktor mailto [University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB) > >]
Antony, Paul mailto [University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB) > >]
Diederich, Nico mailto [University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB) > >]
Buttini, Manuel mailto [University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB) > >]
Kolodkin, Alexey mailto [University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB) > >]
Kodama, Akihiko [Tokyo Medical and Dental University > Faculty of Medicine]
Satagopam, Venkata mailto [University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB) > >]
Biryukov, Maria mailto [University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB) > >]
Eifes, Serge mailto [University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB) > >]
del Sol Mesa, Antonio mailto [University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB) > >]
Schneider, Reinhard mailto [University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB) > >]
Kitano, Hiroaki mailto [The Systems Biology Institute (SBI) - Japan]
Balling, Rudi mailto [University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB) > >]
9-Mar-2013
85x120cm
Yes
No
International
The 11th International Conference on Alzheimer's & Parkinson's Diseases
06-03-2013 to 10-03-2013
AD/PD
Florence
Italy
[en] Parkinson’s disease ; Molecular neuropathology ; Knowledge repository ; Bioinformatics
[en] Objectives: The pathogenesis of Parkinson's Disease (PD) is multi-factorial and age-related, implicating various genetic and environmental factors. It becomes increasingly important to develop new approaches to organize and explore the exploding knowledge of this field.
Methods: The published knowledge on pathways implicated in PD, such as synaptic and mitochondrial dysfunction, alpha-synuclein pathobiology, failure of protein degradation systems and neuroinflammation has been organized and represented using CellDesigner. This repository has been linked to a framework of bioinformatics tools including text mining, database annotation, large-scale data integration and network analysis. The interface for online curation of the repository has been established using Payao tool.
Results: We present the PD map, a computer-based knowledge repository, which includes molecular mechanisms of PD in a visually structured and standardized way. A bioinformatics framework that facilitates in-depth knowledge exploration, extraction and curation supports the map. We discuss the insights gained from PD map-driven text mining of a corpus of over 50 thousands full text PD-related papers, integration and visualization of gene expression in post mortem brain tissue of PD patients with the map, as well as results of network analysis.
Conclusions: The knowledge repository of disease-related mechanisms provides a global insight into relationships between different pathways and allows considering a given pathology in a broad context. Enrichment with available text and bioinformatics databases as well as integration of experimental data supports better understanding of complex mechanisms of PD and formulation of novel research hypotheses.
Luxembourg Centre for Systems Biomedicine (LCSB): Experimental Neurobiology (Balling Group)
University of Luxembourg - UL
Researchers ; Professionals ; Students ; Others
http://hdl.handle.net/10993/2261
http://adpd.ekonnect.co/ADPD_443/poster_53520/program.aspx
Presented by Christophe Trefois at the conference.

File(s) associated to this reference

Fulltext file(s):

FileCommentaryVersionSizeAccess
Open access
ADPD PD map poster v6.pdfPresented by Christophe TrefoisPublisher postprint4.67 MBView/Open

Bookmark and Share SFX Query

All documents in ORBilu are protected by a user license.