Reference : Biomarkers of postoperative delirium and cognitive dysfunction
Scientific journals : Article
Life sciences : Multidisciplinary, general & others
Human health sciences : Neurology
Human health sciences : Surgery
http://hdl.handle.net/10993/22380
Biomarkers of postoperative delirium and cognitive dysfunction
English
Androsova, Ganna mailto [University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB) >]
Krause, Roland mailto [University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB) >]
Winterer, Georg [> >]
Schneider, Reinhard mailto [University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB) >]
2015
Frontiers in Aging Neuroscience
7
112
Yes
International
1663-4365
[en] Elderly surgical patients frequently experience postoperative delirium (POD) and the subsequent development of postoperative cognitive dysfunction (POCD). Clinical features include deterioration in cognition, disturbance in attention and reduced awareness of the environment and result in higher morbidity, mortality and greater utilization of social financial assistance. The aging Western societies can expect an increase in the incidence of POD and POCD. The underlying pathophysiological mechanisms have been studied on the molecular level albeit with unsatisfying small research efforts given their societal burden. Here, we review the known physiological and immunological changes and genetic risk factors, identify candidates for further studies and integrate the information into a draft network for exploration on a systems level. The pathogenesis of these postoperative cognitive impairments is multifactorial; application of integrated systems biology has the potential to reconstruct the underlying network of molecular mechanisms and help in the identification of prognostic and diagnostic biomarkers.
Researchers
http://hdl.handle.net/10993/22380
10.3389/fnagi.2015.00112
http://www.frontiersin.org/aging_neuroscience/10.3389/fnagi.2015.00112/abstract
FP7 ; BioCog

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