Reference : The role of IP3R clustering in Ca2+ signaling.
Scientific journals : Article
Life sciences : Multidisciplinary, general & others
http://hdl.handle.net/10993/22351
The role of IP3R clustering in Ca2+ signaling.
English
Skupin, Alexander mailto [University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB) >]
Falcke, Martin [> >]
2008
Genome informatics. International Conference on Genome Informatics
20
15-24
Yes (verified by ORBilu)
International
0919-9454
Japan
[en] Animals ; Calcium/physiology ; Calcium-Transporting ATPases/metabolism ; Cytosol/physiology ; Endoplasmic Reticulum/physiology ; Inositol 1,4,5-Trisphosphate Receptors/physiology ; Ion Channels/physiology ; Probability ; Signal Transduction
[en] Ca(2+) is the most important second messenger controlling a variety of intracellular processes by oscillations of the cytosolic Ca(2+) concentration. These oscillations occur by Ca(2+) release from the endoplasmic reticulum (ER) into the cytosol through channels and the re-uptake of Ca(2+) into the ER by pumps. A common channel type present in many cell types is the inositol trisphosphate receptor (IP(3)R), which is activated by IP(3) and Ca(2+) itself leading to Ca(2+) induced Ca(2+) release (CICR). We have shown in an experimental study, that Ca(2+) oscillations are sequences of random spikes that occur by wave nucleation. We use here our recently developed model for Ca(2+) dynamics in 3 dimension to illuminate the role of IP(3)R clustering within spatial extended systems.
http://hdl.handle.net/10993/22351

File(s) associated to this reference

Fulltext file(s):

FileCommentaryVersionSizeAccess
Limited access
Skupin_genome_informatics_2008.pdfPublisher postprint277.86 kBRequest a copy

Bookmark and Share SFX Query

All documents in ORBilu are protected by a user license.