Reference : Discovering pair-wise genetic interactions: an information theory-based approach.
Scientific journals : Article
Life sciences : Multidisciplinary, general & others
http://hdl.handle.net/10993/22343
Discovering pair-wise genetic interactions: an information theory-based approach.
English
Ignac, Tomasz mailto [University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB) >]
Skupin, Alexander mailto [University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB) >]
Sakhanenko, Nikita A. [> >]
Galas, David J. [> >]
2014
PloS one
9
3
e92310
Yes (verified by ORBilu)
International
1932-6203
1932-6203
United States
[en] Phenotypic variation, including that which underlies health and disease in humans, results in part from multiple interactions among both genetic variation and environmental factors. While diseases or phenotypes caused by single gene variants can be identified by established association methods and family-based approaches, complex phenotypic traits resulting from multi-gene interactions remain very difficult to characterize. Here we describe a new method based on information theory, and demonstrate how it improves on previous approaches to identifying genetic interactions, including both synthetic and modifier kinds of interactions. We apply our measure, called interaction distance, to previously analyzed data sets of yeast sporulation efficiency, lipid related mouse data and several human disease models to characterize the method. We show how the interaction distance can reveal novel gene interaction candidates in experimental and simulated data sets, and outperforms other measures in several circumstances. The method also allows us to optimize case/control sample composition for clinical studies.
Luxembourg Centre for Systems Biomedicine (LCSB): Integrative Cell Signalling (Skupin Group) ; Luxembourg Centre for Systems Biomedicine (LCSB): Experimental Neurobiology (Balling Group) ; Luxembourg Centre for Systems Biomedicine (LCSB): Bioinformatics Core (R. Schneider Group)
http://hdl.handle.net/10993/22343
10.1371/journal.pone.0092310

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