Reference : Inflammation Promotes a Conversion of Astrocytes into Neural Progenitor Cells via NF-...
Scientific journals : Article
Life sciences : Biotechnology
Life sciences : Multidisciplinary, general & others
Human health sciences : Immunology & infectious disease
Human health sciences : Neurology
http://hdl.handle.net/10993/22027
Inflammation Promotes a Conversion of Astrocytes into Neural Progenitor Cells via NF-κB Activation
English
Gabel, Sebastien []
Koncina, Eric [University of Luxembourg > Faculty of Science, Technology and Communication (FSTC) > Life Science Research Unit >]
Dorban, Gauthier []
Heurtaux, Tony [University of Luxembourg > Faculty of Science, Technology and Communication (FSTC) > Life Science Research Unit >]
Birck, Cindy [University of Luxembourg > Faculty of Science, Technology and Communication (FSTC) > Life Science Research Unit >]
Glaab, Enrico mailto [University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB) > >]
Michelucci, Alessandro [University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB) > >]
Heuschling, Paul [University of Luxembourg > Faculty of Science, Technology and Communication (FSTC) > >]
Grandbarbe, Luc []
17-Sep-2015
Molecular Neurobiology
53
8
5041-5055
Yes
International
[en] Astrocyte ; Inflammation ; NF-kB ; Dedifferentiation ; Neural progenitor cells
[en] Brain inflammation, a common feature in neurodegenerative diseases, is a complex series of events, which can be detrimental and even lead to neuronal death. Nonetheless, several studies suggest that inflammatory signals are also positively influencing neural cell proliferation, survival, migration, and differentiation. Recently, correlative studies suggested that astrocytes are able to dedifferentiate upon injury and may thereby re-acquire neural stem cell (NSC) potential. However, the mechanism underlying this dedifferentiation process upon injury remains unclear. Here, we report that during the early response of reactive gliosis, inflammation induces a conversion of mature astrocytes into neural progenitors. A TNF treatment induces the decrease of specific astrocyte markers, such as glial fibrillary acidic protein (GFAP) or genes related to glycogen metabolism, while a subset of these cells re-expresses immaturity markers, such as CD44, Musashi-1, and Oct4. Thus, TNF treatment results in the appearance of cells that exhibit a neural progenitor phenotype and are able to proliferate and differentiate into neurons and/or astrocytes. This dedifferentiation process is maintained as long as TNF is present in the culture medium. In addition, we highlight a role for Oct4 in this process, since the TNF-induced dedifferentiation can be prevented by inhibiting Oct4 expression. Our results show that activation of the NF-κB pathway through TNF plays an important role in the dedifferentiation of astrocytes via the re-expression of Oct4. These findings indicate that the first step of reactive gliosis is in fact a dedifferentiation process of resident astrocytes mediated by the NF-κB pathway.
Luxembourg Centre for Systems Biomedicine (LCSB): Biomedical Data Science (Glaab Group)
Fonds National de la Recherche - FnR ; University of Luxembourg - UL
Researchers ; Professionals ; Students
http://hdl.handle.net/10993/22027
10.1007/s12035-015-9428-3
The original publication is available at www.springerlink.com (http://link.springer.com/article/10.1007/s12035-015-9428-3/fulltext.html)

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