Reference : Shared alterations in the human brain transcriptome during adult aging and in Parkins...
Scientific congresses, symposiums and conference proceedings : Poster
Life sciences : Biotechnology
Human health sciences : Neurology
http://hdl.handle.net/10993/21432
Shared alterations in the human brain transcriptome during adult aging and in Parkinson's disease
English
Glaab, Enrico mailto [University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB) > >]
Schneider, Reinhard mailto [University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB) > >]
15-Jun-2015
Yes
International
EMBO Symposium on Mechanisms of Neurodegeneration 2015
from 14-06-2015 to 17-06-2015
European Molecular Biology Organization, European Molecular Biology Laboratory
Heidelberg
Germany
[en] Parkinson's disease ; aging ; brain ; biomarker ; neurodegeneration ; pathway ; network ; analysis ; bioinformatics ; statistics ; meta-analysis
[en] Aging-related biomolecular changes in the human brain are thought to be associated with an increased risk for neurodegenerative diseases. In particular, aging and Parkinson’s disease (PD) share various molecular hallmarks, including a gradual decline in dopamine synthesis and increased levels of deleted mitochondrial DNA. While some specific mechanistic links between brain aging and PD have been proposed and investigated previously, systematic analyses of shared molecular alterations at a genome-scale level are required to obtain a better understanding of the affected cellular processes and their interrelations.
We present a joint analysis of high-throughput brain transcriptomics data from PD patients and unaffected individuals from different adult age groups using a statistical meta-analysis and a recently published pathway and network analysis approach.
Our analyses provide statistical evidence for specific functional associations between molecular network changes in PD and aging, identify new significant joint pathway deregulations and suggest mechanistic explanations for the observed age-dependence of PD risk.
Luxembourg Centre for Systems Biomedicine (LCSB)
Fonds National de la Recherche - FnR
Researchers ; Professionals ; Students
http://hdl.handle.net/10993/21432
FnR ; FNR5782168 > Enrico Glaab > ExPDIENT > Exploring Parkinson’s Disease Inhibitor Efficacy on a Non-dopaminergic Target > 01/12/2013 > 31/05/2016 > 2013

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