Reference : Computational representation and hemodynamic characterization of in vivo acquired sev...
Scientific journals : Article
Engineering, computing & technology : Multidisciplinary, general & others
Computational Sciences
http://hdl.handle.net/10993/20941
Computational representation and hemodynamic characterization of in vivo acquired severe stenotic renal artery geometries using turbulence modeling
English
Kagadis, George [University of Patras > Department of Medical Physics - School of Medicine]
Skouras, Eugene [University of Patras > Department of Chemical Engineering > > ; Foundation for Research and Technology > Institute of Chemical Engineering and High Temperature Chemical Processes]
Bourantas, Georgios mailto [University of Luxembourg > Faculty of Science, Technology and Communication (FSTC) > Engineering Research Unit >]
Paraskeva, Christaki [University of Patras > Department of Chemical Engineering > > ; Foundation for Research and Technology > Institute of Chemical Engineering and High Temperature Chemical Processes]
Katsanos, Konstantinos [University of Patras > Department of Radiology - School of Medicine]
Karnabatidis, Dimitris [University of Patras > Department of Radiology - School of Medicine]
Nikiforidis, George [University of Patras > Department of Medical Physics - School of Medicine]
30-Jun-2008
Medical Engineering & Physics
Butterworth Heinemann
30
5
647-660
Yes (verified by ORBilu)
1350-4533
1873-4030
London
United Kingdom
[en] Computational fluid dynamics ; hemodynamics ; renal artery stenosis ; Computer- Aided Therapeutic Planning ; simulated reconstruction ; turbulent flow ; segmentation, ; Computed Tomography
[en] The present study reports on computational fluid dynamics in the case of severe renal artery stenosis (RAS). An anatomically realistic model of a renal artery was reconstructed from CT scans, and used to conduct CFD simulations of blood flow across RAS. The recently developed Shear Stress Transport turbulence model was pivotally applied in the simulation of blood flow in the region of interest. Blood flow was studied in vivo under the presence of RAS and subsequently in simulated cases before the development of RAS, and after endovascular stent implantation. The pressure gradients in the RAS case were many orders of magnitude larger than in the healthy case. The presence of RAS increased flow resistance, which led to considerably lower blood flow rates. A simulated stent in place of the RAS decreased the flow resistance at levels proportional to, and even lower than, the simulated healthy case without the RAS. The wall shear stresses, differential pressure profiles, and net forces exerted on the surface of the atherosclerotic plaque at peak pulse were shown to be of relevant high distinctiveness, so as to be considered potential indicators of hemodynamically significant RAS.
http://hdl.handle.net/10993/20941

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