Reference : Mathematical models of circadian Ca2+ oscillations
Scientific congresses, symposiums and conference proceedings : Paper published in a book
Engineering, computing & technology : Multidisciplinary, general & others
http://hdl.handle.net/10993/20787
Mathematical models of circadian Ca2+ oscillations
English
Neil, D. [> >]
Goncalves, Jorge mailto [University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB) > >]
Webb, A.R. mailto []
2007
Proceedings of the eighth International Conference on Systems Biology
Yes
The eighth International Conference on Systems Biology
October 1 -6, 2007
Long Beach
USA
[en] In the model plant Arabidopsis thaliana, the concentration of cytosolic-free Ca2+ ([Ca2+]cyt) oscillates with a circadian rhythm. We are investigating the regulation and role of these oscillations both experimentally and mathematically. Through systems identification, we have developed simple mathematical models from a single experiment measuring [Ca2+]cyt and the promoter activity of CIRCADIAN CLOCK ASSOCIATED 1 (CCA1). Through validation with 4 contrasting datasets, including a clock-arrhythmic transgenic line (CCA1 overexpressor), we demonstrate the necessity for a light input pathway to regulate basal [Ca2+]cyt levels.
http://hdl.handle.net/10993/20787
http://www.icsb-2007.org/proceedings/abstracts/F08.pdf

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