Reference : Systematic genome assessment of B-vitamin biosynthesis suggests co-operation among gu...
Scientific journals : Article
Life sciences : Multidisciplinary, general & others
http://hdl.handle.net/10993/20707
Systematic genome assessment of B-vitamin biosynthesis suggests co-operation among gut microbes
English
Magnusdottir, Stefania mailto [University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB) > >]
Ravcheev, Dmitry mailto [University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB) > >]
de Crecy-Lagard, Valerie [University of Florida > Department of Microbiology and Cell Science, Institute of Food and Agricultural Sciences and Genetics Institute]
Thiele, Ines mailto [University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB) > >]
Apr-2015
Frontiers in Genetics
6
148
Yes (verified by ORBilu)
International
1664-8021
[en] Genome annotation ; human gut microbiota ; B-vitamin biosynthesis ; PubSEED ; subsystem
[en] The human gut microbiota supplies its host with essential nutrients, including B-vitamins. Using the PubSEED platform, we systematically assessed the genomes of 256 common human gut bacteria for the presence of biosynthesis pathways for eight B-vitamins: biotin, cobalamin, folate, niacin, pantothenate, pyridoxine, riboflavin, and thiamin. On the basis of the presence and absence of genome annotations, we predicted that each of the eight vitamins was produced by 40–65% of the 256 human gut microbes. The distribution of synthesis pathways was diverse; some genomes had all eight biosynthesis pathways, whereas others contained no de novo synthesis pathways. We compared our predictions to experimental data from 16 organisms and found 88% of our predictions to be in agreement with published data. In addition, we identified several pairs of organisms whose vitamin synthesis pathway pattern complemented those of other organisms. This analysis suggests that human gut bacteria actively exchange B-vitamins among each other, thereby enabling the survival of organisms that do not synthesize any of these essential cofactors. This result indicates the co-evolution of the gut microbes in the human gut environment. Our work presents the first comprehensive assessment of the B-vitamin synthesis capabilities of the human gut microbiota. We propose that in addition to diet, the gut microbiota is an important source of B-vitamins, and that changes in the gut microbiota composition can severely affect our dietary B-vitamin requirements.
Luxembourg Centre for Systems Biomedicine (LCSB): Molecular Systems Physiology (Thiele Group)
http://hdl.handle.net/10993/20707
10.3389/fgene.2015.00148
http://journal.frontiersin.org/article/10.3389/fgene.2015.00148/abstract

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