Reference : Genome-scale modeling for metabolic engineering
Scientific journals : Article
Life sciences : Multidisciplinary, general & others
http://hdl.handle.net/10993/20672
Genome-scale modeling for metabolic engineering
English
Simeonidis, Vangelis mailto [University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB) > >]
Price, Nathan [Institute for Systems Biology - ISB]
13-Jan-2015
Journal of Industrial Microbiology & Biotechnology
Springer
42
3
Metabolic Engineering
327–338
Yes (verified by ORBilu)
International
1367-5435
1476-5535
Berlin
Germany
[en] flux balance analysis ; metabolic engineering ; metabolic reconstructions ; automated network reconstruction ; gene regulatory networks
[en] We focus on the application of constraint-based methodologies and, more specifically, flux balance analysis in the field of metabolic engineering, and enumerate recent developments and successes of the field. We also review computational frameworks that have been developed with the express purpose of automatically selecting optimal gene deletions for achieving improved production of a chemical of interest. The application of flux balance analysis methods in rational metabolic engineering requires a metabolic network reconstruction and a corresponding in silico metabolic model for the microorganism in question. For this reason, we additionally present a brief overview of automated reconstruction techniques. Finally, we emphasize the importance of integrating metabolic networks with regulatory information—an area which we expect will become increasingly important for metabolic engineering—and present recent developments in the field of metabolic and regulatory integration.
Luxembourg Centre for Systems Biomedicine (LCSB): Experimental Neurobiology (Balling Group)
Researchers ; Professionals ; Students ; General public
http://hdl.handle.net/10993/20672
10.1007/s10295-014-1576-3
http://link.springer.com/article/10.1007%2Fs10295-014-1576-3

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