Reference : Modeling time delay in the NFkappaB signaling pathway following low dose IL-1 stimulation.
Scientific journals : Article
Life sciences : Multidisciplinary, general & others
http://hdl.handle.net/10993/2064
Modeling time delay in the NFkappaB signaling pathway following low dose IL-1 stimulation.
English
Witt, Johannes [> >]
Barisic, Sandra [> >]
Sawodny, Oliver [> >]
Ederer, Michael [> >]
Kulms, Dagmar [> >]
Sauter, Thomas mailto [University of Luxembourg > Faculty of Science, Technology and Communication (FSTC) > Life Science Research Unit >]
2011
EURASIP Journal on Bioinformatics & Systems Biology
2011
1
3
Yes (verified by ORBilu)
1687-4145
1687-4153
Germany
[en] Stimulation of human epithelial cells with IL-1 (10 ng/ml) + UVB radiation results in sustained NFkappaB activation caused by continuous IKKbeta phosphorylation. We have recently published a strictly reduced ordinary differential equation model elucidating the involved mechanisms. Here, we compare model extensions for low IL-1 doses (0.5 ng/ml), where delayed IKKbeta phosphorylation is observed. The extended model including a positive regulatory element, most likely auto-ubiquitination of TRAF6, reproduces the observed experimental data most convincingly. The extension is shown to be consistent with the original model and contains very sensitive processes which may serve as potential intervention targets.
http://hdl.handle.net/10993/2064

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