Reference : Reconstruction of biological networks through gene silencing and overexpression
Scientific congresses, symposiums and conference proceedings : Paper published in a book
Life sciences : Multidisciplinary, general & others
http://hdl.handle.net/10993/20440
Reconstruction of biological networks through gene silencing and overexpression
English
Russell, H. [> >]
Goncalves, Jorge mailto [University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB) > >]
Neil, D. [> >]
Sean, W. mailto [> >]
2007
Proceedings of the eighth International Conference on Systems Biology
Yes
The eighth International Conference on Systems Biology
October 1 -6, 2007
Long Beach
USA
[en] Many methods that exist for reconstructing biological networks take into account assumptions of sparsity or already known relationships among states of the network. We show that we can completely characterize the relationships among observed states and inputs in a linearized network through a series of easily performed biological experiments--inducible overexpression and gene silencing. We briefly review dynamical structure and give conditions for a set of experiments that will give all necessary information to obtain the structure.
http://hdl.handle.net/10993/20440

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