Reference : How metabolites modulate metabolic flux
Scientific journals : Article
Life sciences : Biochemistry, biophysics & molecular biology
http://hdl.handle.net/10993/20203
How metabolites modulate metabolic flux
English
Wegner, André mailto [University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB) > >]
Meiser, Johannes mailto [University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB) > >]
Weindl, Daniel mailto [University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB) > >]
Hiller, Karsten mailto [University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB) > >]
2015
Current Opinion in Biotechnology
Elsevier Science
34
16-22
Yes (verified by ORBilu)
International
0958-1669
[en] Metabolism ; Regulation ; Fluxes
[en] Adaptation to metabolic needs and changing environments is a
basic requirement of every living system. These adaptations
can be very quick and mild or slower but more drastic. In any
case, cells have to constantly monitor their metabolic state and
requirements.In this article we review general concepts as well
as recent advances on how metabolites can regulate
metabolic fluxes. We discuss how cells sense metabolite
levels and how changing metabolite levels regulate metabolic
enzymes on different levels, from specific allosteric regulation
to global transcriptional regulation. We thereby focus on local
metabolite sensing in mammalian cells and show that several
major discoveries have only very recently been made.
Luxembourg Centre for Systems Biomedicine (LCSB): Metabolomics (Hiller Group)
Fonds National de la Recherche - FnR
Researchers ; Professionals ; Students ; Others
http://hdl.handle.net/10993/20203
10.1016/j.copbio.2014.11.008

File(s) associated to this reference

Fulltext file(s):

FileCommentaryVersionSizeAccess
Open access
1-s2.0-S0958166914001955-main.pdfPublisher postprint933 kBView/Open

Bookmark and Share SFX Query

All documents in ORBilu are protected by a user license.