Reference : Community-integrated omics links dominance of a microbial generalist to fine-tuned re...
Scientific journals : Article
Life sciences : Environmental sciences & ecology
Life sciences : Genetics & genetic processes
Life sciences : Microbiology
http://hdl.handle.net/10993/18965
Community-integrated omics links dominance of a microbial generalist to fine-tuned resource usage
English
Muller, Emilie mailto [University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB) > >]
Pinel, Nicolas [> >]
Laczny, Cedric Christian mailto [University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB) > >]
Hoopmann, Michael [> >]
Narayanasamy, Shaman mailto [University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB) > >]
Lebrun, Laura mailto [University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB) > >]
Roume, Hugo [University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB) > >]
Lin, Jake mailto [University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB) > >]
May, Patrick mailto [University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB) > >]
Hicks, Nathan [> >]
Buschart, Anna mailto [University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB) > >]
Wampach, Linda mailto [University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB) > >]
Liu, Cindy [> >]
Price, Lance [> >]
Gillece, John [> >]
Guignard, Cédric [> >]
Schupp, James [> >]
Vlassis, Nikos [University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB) > >]
Baliga [> >]
Moritz, Robert [> >]
Keim, Paul [> >]
Wilmes, Paul mailto [University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB) > >]
Nov-2014
Nature Communications
Nature Pub.lishing Group
Yes (verified by ORBilu)
International
2041-1723
London
United Kingdom
[en] Microbial communities are complex and dynamic systems that are primarily structured
according to their members’ ecological niches. To investigate how niche breadth (generalist
versus specialist lifestyle strategies) relates to ecological success, we develop and apply an
integrative workflow for the multi-omic analysis of oleaginous mixed microbial communities
from a biological wastewater treatment plant. Time- and space-resolved coupled metabolomic
and taxonomic analyses demonstrate that the community-wide lipid accumulation
phenotype is associated with the dominance of the generalist bacterium Candidatus Microthrix
spp. By integrating population-level genomic reconstructions (reflecting fundamental
niches) with transcriptomic and proteomic data (realised niches), we identify finely tuned
gene expression governing resource usage by Candidatus Microthrix parvicella over time.
Moreover, our results indicate that the fluctuating environmental conditions constrain the
accumulation of genetic variation in Candidatus Microthrix parvicella likely due to fitness
trade-offs. Based on our observations, niche breadth has to be considered as an important
factor for understanding the evolutionary processes governing (microbial) population sizes
and structures in situ.
Luxembourg Centre for Systems Biomedicine (LCSB): Eco-Systems Biology (Wilmes Group) ; Luxembourg Centre for Systems Biomedicine (LCSB): Bioinformatics Core (R. Schneider Group) ; University of Luxembourg: High Performance Computing - ULHPC ; Luxembourg Centre for Systems Biomedicine (LCSB): Machine Learning (Vlassis Group)
Researchers
http://hdl.handle.net/10993/18965
10.1038/ncomms6603
http://www.nature.com/ncomms/2014/141126/ncomms6603/full/ncomms6603.html

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