Reference : Estrogen receptor alpha interacts with 17beta-hydroxysteroid dehydrogenase type 10 in...
Scientific journals : Article
Human health sciences : Multidisciplinary, general & others
http://hdl.handle.net/10993/18372
Estrogen receptor alpha interacts with 17beta-hydroxysteroid dehydrogenase type 10 in mitochondria.
English
Jazbutyte, Virginija [> >]
Kehl, Franz [> >]
Neyses, Ludwig mailto [University of Luxembourg > Research Office]
Pelzer, Theo [> >]
2009
Biochemical and biophysical research communications
384
4
450-4
Yes (verified by ORBilu)
International
0006-291X
1090-2104
United States
[en] 3-Hydroxyacyl CoA Dehydrogenases/genetics/metabolism ; Animals ; Cell Nucleus/enzymology ; Estrogen Receptor alpha/genetics/metabolism ; Gene Library ; Humans ; Immunoprecipitation ; Mitochondria, Heart/enzymology ; Myocytes, Cardiac/enzymology/ultrastructure ; Rats ; Two-Hybrid System Techniques
[en] Estrogen receptor alpha (ERalpha) is present in the nucleus, the cytosol and in mitochondria. The rat ERalpha ligand binding domain was employed as bait in a bacterial two-hybrid screening of a human heart cDNA library to detect novel protein-protein interaction partners of ERalpha in the heart. 17beta-Hydroxysteroid dehydrogenase type 10 (17beta-HSD10), which converts potent (17beta-estradiol) to less potent estrogens (estrone), co-localized with 17beta-HSD10 in the mitochondria of rat cardiac myocytes. GST pull-down experiments confirmed the interaction of ERalpha and 17beta-HSD10. These findings suggest that the ERalpha estrogen receptor might be involved in regulating intracellular estrogen levels by modulating 17beta-HSD10 activity.
http://hdl.handle.net/10993/18372
10.1016/j.bbrc.2009.04.139
http://www.sciencedirect.com/science/article/pii/S0006291X09008675

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