Reference : Effects of estrogen on skeletal myoblast growth.
Scientific journals : Article
Human health sciences : Cardiovascular & respiratory systems
http://hdl.handle.net/10993/18346
Effects of estrogen on skeletal myoblast growth.
English
Kahlert, S. [> >]
Grohe, C. [> >]
Karas, R. H. [> >]
Lobbert, K. [> >]
Neyses, Ludwig mailto [University of Luxembourg > Research Office]
Vetter, H. [> >]
1997
Biochemical and biophysical research communications
232
2
373-8
Yes
International
0006-291X
UNITED STATES
[en] Animals ; Blotting, Western ; Cell Division/drug effects ; Cell Line ; DNA-Binding Proteins/biosynthesis/genetics ; Early Growth Response Protein 1 ; Estrogens/metabolism/pharmacology/physiology ; Gene Expression Regulation/drug effects ; Immediate-Early Proteins ; Mice ; Muscle Development ; Muscle, Skeletal/cytology/drug effects/growth & development ; Rats ; Receptors, Estrogen/metabolism/physiology ; Transcription Factors/biosynthesis/genetics ; Transcriptional Activation
[en] To determine the role of estrogen in skeletal muscle growth, we investigated estrogen receptor-mediated effects on proliferation in skeletal myoblasts. In L6, C2C12 and Sol8 myoblasts estrogen receptor was demonstrated by immunoblotting, immunofluorescence microscopy and transfection studies. Estrone induced a significant increase in myoblast growth whereas 17 beta-estradiol had no effect. Furthermore in L6-cells estrone (c-fos: 3.9-fold, egr-1: 4.6-fold) induced immediate-early gene induction significantly stronger than 17 beta-estradiol (c-fos: 1.7-fold, egr-1: 2.3-fold; p < 0.05). Skeletal myoblasts express functional estrogen receptors. Estrogens differ in the activation of skeletal myoblast growth and immediate-early gene induction.
http://hdl.handle.net/10993/18346
10.1006/bbrc.1997.6223
http://www.sciencedirect.com/science/article/pii/S0006291X97962239

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