Reference : The cardiovascular phenotype of a mouse model of acromegaly.
Scientific journals : Article
Human health sciences : Cardiovascular & respiratory systems
http://hdl.handle.net/10993/18342
The cardiovascular phenotype of a mouse model of acromegaly.
English
Izzard, Ashley S. [> >]
Emerson, Michael [> >]
Prehar, Sukhpal [> >]
Neyses, Ludwig mailto [University of Luxembourg > Research Office]
Trainer, Peter [> >]
List, Edward O. [> >]
Kopchick, John J. [> >]
Heagerty, Anthony M. [> >]
2009
Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society
19
5
413-9
Yes (verified by ORBilu)
International
1096-6374
1532-2238
Scotland
[en] Acromegaly/metabolism/physiopathology ; Animals ; Cardiovascular System/physiopathology ; Growth Hormone/genetics/metabolism ; Mice ; Mice, Transgenic ; Myocardial Contraction/physiology ; Organ Size ; Phenotype
[en] BACKGROUND: Although, it is accepted that there is an excess of cardiovascular mortality in acromegaly, it is uncertain whether this is due to the direct effects of growth hormone-induced-cardiomyopathy or is a consequence of atherosclerosis secondary to the metabolic syndrome often observed in this condition. Direct comparison of a mouse model of acromegaly to a mouse model of Laron's syndrome allowed us to carry out detailed phenotyping and better understand the role GH plays in the circulatory system. METHODS AND RESULTS: Transgenic mice that overexpress the growth hormone gene (GH) developed gigantism, including insulin resistance and higher blood pressures commensurate with increased body mass. In these giant mice, the hearts were hypertrophied but haemodynamic studies suggested contractile function was normal. Segments of small arteries mounted in a pressure myograph showed vascular wall hypertrophy but a preserved lumen diameter. Vascular contractile function was normal. Mice in which the GH receptor gene was disrupted or 'knocked out' were dwarf and had low blood pressure, small hearts and blood vessels but a normally functioning circulation. Correlations of body mass with cardiovascular parameters suggested that blood pressure and structural characteristics develop in line with body size. CONCLUSION: In this transgenic mouse model of acromegaly, there is cardiac and vascular hypertrophy commensurate with GH excess but normal function. Our findings support the contention that the excess mortality in this condition may be due to the development of hypertrophic cardiomyopathy rather than increased rates of atherosclerotic coronary artery disease.
http://hdl.handle.net/10993/18342
10.1016/j.ghir.2008.12.006
http://www.sciencedirect.com/science/article/pii/S1096637408001469

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