Reference : The molecular basis of myocardial hypertrophy and heart failure.
Scientific journals : Article
Human health sciences : Cardiovascular & respiratory systems
http://hdl.handle.net/10993/18311
The molecular basis of myocardial hypertrophy and heart failure.
English
Ritter, Oliver [> >]
Neyses, Ludwig mailto [University of Luxembourg > Research Office]
2003
Trends in molecular medicine
9
7
313-21
Yes (verified by ORBilu)
International
1471-4914
England
[en] Cardiac Output, Low/genetics/metabolism ; Cardiomegaly/genetics/metabolism ; Humans ; Myocardial Contraction ; Phenotype
[en] Heart failure (HF) is the inability of the heart to cope with the metabolic demands of the periphery. It is the common end-stage of many frequent cardiac diseases and is characterized by relentless progression. Mechanisms of progression include renal sodium and water retention, neurohumoral activation and alterations of the protein composition (gene programme) of the heart itself. In this review, we explain the often confusing terminology in the subject, briefly touch upon the peripheral mechanisms of HF, and then focus on the changes in the gene programme of the failing heart and the molecular mechanisms leading to them. Understanding the basic processes underlying HF will help uninitiated readers to gain insight into recent novel approaches to its treatment.
http://hdl.handle.net/10993/18311
10.1016/S1471-4914(03)00114-X
http://www.sciencedirect.com/science/article/pii/S147149140300114X#

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