Reference : A meta-analysis of glucose-insulin-potassium therapy for treatment of acute myocardia...
Scientific journals : Article
Human health sciences : Cardiovascular & respiratory systems
http://hdl.handle.net/10993/17617
A meta-analysis of glucose-insulin-potassium therapy for treatment of acute myocardial infarction.
English
Mamas, Mamas A. [> >]
Neyses, Ludwig mailto [University of Luxembourg > Research Office]
Fath-Ordoubadi, Farzin [> >]
2010
Experimental & Clinical Cardiology
15
2
e20-4
Yes
International
1205-6626
1918-1515
Canada
[en] Insulin ; Meta-analysis ; Myocardial infarction
[en] BACKGROUND: Glucose-insulin-potassium (GIK) therapy has been proposed to provide metabolic support to ischemic myocardium. A meta-analysis that included 1932 patients performed 10 years previously demonstrated that GIK therapy may have an important role in reducing mortality after acute myocardial infarction (AMI). Since then, many larger randomized trials investigating the role of GIK in the setting of AMI have been published; hence, the present study repeats the previous meta-analysis performed by the current authors to include these trials. METHOD AND RESULTS: A systematic MEDLINE search for all randomized, placebo-controlled studies of GIK therapy in the setting of AMI was conducted and a meta-analysis of the mortality data was performed. A total of 16 randomized trials from 1966 to 2008 were identified, with 28,374 patients included in the current meta-analysis. There was a total of 1367 deaths (9.6%) in the GIK group, with 1351 deaths (9.6%) in the control group. Meta-analysis did not reveal any benefit from GIK treatment (OR 1.0; 95% CI 0.9 to 1.1; P=0.9). Subgroup analysis of patients given high-dose GIK and in patients in whom reperfusion was not obtained did not demonstrate a benefit from GIK therapy. CONCLUSION: A meta-analysis of 16 randomized trials that spanned 40 years and involved more than 28,000 patients did not reveal any mortality benefit for ST segment elevation AMI using GIK therapy when data from the modern thrombolysis/primary percutaneous coronary intervention era were included.
http://hdl.handle.net/10993/17617
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2898530/

File(s) associated to this reference

Fulltext file(s):

FileCommentaryVersionSizeAccess
Open access
A meta-analysis of glucose-insulin-potassium therapy for treatment of acute myocardial infarction.pdfPublisher postprint525.03 kBView/Open

Bookmark and Share SFX Query

All documents in ORBilu are protected by a user license.