Reference : Applying systems biology methods to the study of human physiology in extreme environments
Scientific journals : Article
Life sciences : Multidisciplinary, general & others
http://hdl.handle.net/10993/17461
Applying systems biology methods to the study of human physiology in extreme environments
English
Edwards, Lindsay [King’s College London > Centre of Human & Aerospace Physiological Sciences, School of Biomedical Sciences]
Thiele, Ines mailto [University of Iceland > Center for Systems Biology]
2013
Extreme Physiology & Medicine
BioMed Central Ltd
2
8
Yes (verified by ORBilu)
International
2046-7648
London
United Kingdom
[en] Systems biology is defined in this review as ‘an iterative process of computational model building and experimental model revision with the aim of understanding or simulating complex biological systems’. We propose that, in practice, systems biology rests on three pillars: computation, the omics disciplines and repeated experimental perturbation of the system of interest. The number of ethical and physiologically relevant perturbations that can be
used in experiments on healthy humans is extremely limited and principally comprises exercise, nutrition, infusions (e.g. Intralipid), some drugs and altered environment. Thus, we argue that systems biology and environmental physiology are natural symbionts for those interested in a system-level understanding of human biology. However, despite excellent progress in high-altitude genetics and several proteomics studies, systems biology research into
human adaptation to extreme environments is in its infancy. A brief description and overview of systems biology in its current guise is given, followed by a mini review of computational methods used for modelling biological systems. Special attention is given to high-altitude research, metabolic network reconstruction and constraint-based modelling.
http://hdl.handle.net/10993/17461
10.1186/2046-7648-2-8

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