Reference : The essential role of lipids in Alzheimer’s disease
Scientific journals : Article
Social & behavioral sciences, psychology : Neurosciences & behavior
Human health sciences : Neurology
http://hdl.handle.net/10993/17248
The essential role of lipids in Alzheimer’s disease
English
Garcia, Pierre mailto [University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB) > >]
Jun-2009
Biochimie
Elsevier
6
Lipids for the future — from agro-resources to human health
804-809
Yes (verified by ORBilu)
International
0300-9084
1638-6183
Paris
France
[en] Neurodegenerative diseases ; Membrane lipids ; Docosahexaenoic acid
[en] In the absence of efficient diagnostic and therapeutic tools, Alzheimer’s disease (AD) is a major public
health concern due to longer life expectancy in the Western countries. Although the precise cause of AD
is still unknown, soluble b-amyloid (Ab) oligomers are considered the proximate effectors of the synaptic
injury and neuronal death occurring in the early stages of AD. Ab oligomers may directly interact with
the synaptic membrane, leading to impairment of synaptic functions and subsequent signalling
pathways triggering neurodegeneration. Therefore, membrane structure and lipid status should be
considered determinant factors in Ab-oligomer-induced synaptic and cell injuries, and therefore AD
progression. Numerous epidemiological studies have highlighted close relationships between AD inci-
dence and dietary patterns. Among the nutritional factors involved, lipids significantly influence AD
pathogenesis. It is likely that maintenance of adequate membrane lipid content could prevent the
production of Ab peptide as well as its deleterious effects upon its interaction with synaptic membrane,
thereby protecting neurons from Ab-induced neurodegeneration. As major constituents of neuronal
lipids, n-3 polyunsaturated fatty acids are of particular interest in the prevention of AD valuable diet
ingredients whose neuroprotective properties could be essential for designing preventive nutrition-
based strategies. In this review, we discuss the functional relevance of neuronal membrane features with
respect to susceptibility to Ab oligomers and AD pathogenesis, as well as the prospective capacities of
lipids to prevent or to delay the disease.
Researchers ; Students
http://hdl.handle.net/10993/17248
10.1016/j.biochi.2009.03.004
http://www.sciencedirect.com/science/article/pii/S0300908409000650

File(s) associated to this reference

Fulltext file(s):

FileCommentaryVersionSizeAccess
Open access
2009 BECHARD-DESBENE-GARCIA The essential role of lipids.pdfPublisher postprint280.71 kBView/Open

Bookmark and Share SFX Query

All documents in ORBilu are protected by a user license.