Reference : Alpha-synuclein repeat variants and survival in Parkinson's disease.
Scientific journals : Article
Life sciences : Genetics & genetic processes
http://hdl.handle.net/10993/17197
Alpha-synuclein repeat variants and survival in Parkinson's disease.
English
Chung, Sun Ju [> >]
Biernacka, Joanna M. [> >]
Armasu, Sebastian M. [> >]
Anderson, Kari [> >]
Frigerio, Roberta [> >]
Aasly, Jan O. [> >]
Annesi, Grazia [> >]
Bentivoglio, Anna Rita [> >]
Brighina, Laura [> >]
Chartier-Harlin, Marie-Christine [> >]
Goldwurm, Stefano [> >]
Hadjigeorgiou, Georgios [> >]
Jasinska-Myga, Barbara [> >]
Jeon, Beom Seok [> >]
Kim, Yun Joong [> >]
Krüger, Rejko mailto [University of Luxembourg > Faculty of Science, Technology and Communication (FSTC) > Life Science Research Unit]
Lesage, Suzanne [> >]
Markopoulou, Katerina [> >]
Mellick, George [> >]
Morrison, Karen E. [> >]
Puschmann, Andreas [> >]
Tan, Eng-King [> >]
Crosiers, David [> >]
Theuns, Jessie [> >]
Van Broeckhoven, Christine [> >]
Wirdefeldt, Karin [> >]
Wszolek, Zbigniew K. [> >]
Elbaz, Alexis [> >]
Maraganore, Demetrius M. [> >]
2014
Movement disorders : official journal of the Movement Disorder Society
Yes (verified by ORBilu)
0885-3185
1531-8257
[en] Parkinson's disease ; association ; gene ; survival ; α-synuclein
[en] OBJECTIVES: To determine whether alpha-synuclein dinucleotide repeat (REP1) genotypes are associated with survival in Parkinson's disease (PD). METHODS: Investigators from the Genetic Epidemiology of Parkinson's Disease Consortium provided REP1 genotypes and baseline and follow-up clinical data for cases. The primary outcome was time to death. Cox proportional hazards regression models were used to assess the association of REP1 genotypes with survival. RESULTS: Twenty-one sites contributed data for 6,154 cases. There was no significant association between alpha-synuclein REP1 genotypes and survival in PD. However, there was a significant association between REP1 genotypes and age at onset of PD (hazard ratio: 1.06; 95% confidence interval: 1.01-1.10; P value = 0.01). CONCLUSIONS: In our large consortium study, alpha-synuclein REP1 genotypes were not associated with survival in PD. Further studies of alpha-synuclein's role in disease progression and long-term outcomes are needed. (c) 2014 International Parkinson and Movement Disorder Society.
Luxembourg Centre for Systems Biomedicine (LCSB): Clinical & Experimental Neuroscience (Krüger Group)
http://hdl.handle.net/10993/17197
10.1002/mds.25841
(c) 2014 Movement Disorder Society.

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