Reference : Genome-wide association study reveals genetic risk underlying Parkinson's disease.
Scientific journals : Article
Life sciences : Genetics & genetic processes
http://hdl.handle.net/10993/17165
Genome-wide association study reveals genetic risk underlying Parkinson's disease.
English
Simon-Sanchez, Javier [> >]
Schulte, Claudia [> >]
Bras, Jose M. [> >]
Sharma, Manu [> >]
Gibbs, J. Raphael [> >]
Berg, Daniela [> >]
Paisan-Ruiz, Coro [> >]
Lichtner, Peter [> >]
Scholz, Sonja W. [> >]
Hernandez, Dena G. [> >]
Krüger, Rejko mailto [University of Luxembourg > Faculty of Science, Technology and Communication (FSTC) > Life Science Research Unit]
Federoff, Monica [> >]
Klein, Christine [> >]
Goate, Alison [> >]
Perlmutter, Joel [> >]
Bonin, Michael [> >]
Nalls, Michael A. [> >]
Illig, Thomas [> >]
Gieger, Christian [> >]
Houlden, Henry [> >]
Steffens, Michael [> >]
Okun, Michael S. [> >]
Racette, Brad A. [> >]
Cookson, Mark R. [> >]
Foote, Kelly D. [> >]
Fernandez, Hubert H. [> >]
Traynor, Bryan J. [> >]
Schreiber, Stefan [> >]
Arepalli, Sampath [> >]
Zonozi, Ryan [> >]
Gwinn, Katrina [> >]
van der Brug, Marcel [> >]
Lopez, Grisel [> >]
Chanock, Stephen J. [> >]
Schatzkin, Arthur [> >]
Park, Yikyung [> >]
Hollenbeck, Albert [> >]
Gao, Jianjun [> >]
Huang, Xuemei [> >]
Wood, Nick W. [> >]
Lorenz, Delia [> >]
Deuschl, Gunther [> >]
Chen, Honglei [> >]
Riess, Olaf [> >]
Hardy, John A. [> >]
Singleton, Andrew B. [> >]
Gasser, Thomas [> >]
2009
Nature genetics
41
12
1308-12
Yes (verified by ORBilu)
1061-4036
1546-1718
United States
[en] Cohort Studies ; Gene Frequency ; Genetic Predisposition to Disease ; Genetic Variation ; Genome-Wide Association Study ; Humans ; Japan ; Parkinson Disease/epidemiology/genetics ; Risk Factors
[en] We performed a genome-wide association study (GWAS) in 1,713 individuals of European ancestry with Parkinson's disease (PD) and 3,978 controls. After replication in 3,361 cases and 4,573 controls, we observed two strong association signals, one in the gene encoding alpha-synuclein (SNCA; rs2736990, OR = 1.23, P = 2.24 x 10(-16)) and another at the MAPT locus (rs393152, OR = 0.77, P = 1.95 x 10(-16)). We exchanged data with colleagues performing a GWAS in Japanese PD cases. Association to PD at SNCA was replicated in the Japanese GWAS, confirming this as a major risk locus across populations. We replicated the effect of a new locus detected in the Japanese cohort (PARK16, rs823128, OR = 0.66, P = 7.29 x 10(-8)) and provide supporting evidence that common variation around LRRK2 modulates risk for PD (rs1491923, OR = 1.14, P = 1.55 x 10(-5)). These data demonstrate an unequivocal role for common genetic variants in the etiology of typical PD and suggest population-specific genetic heterogeneity in this disease.
Luxembourg Centre for Systems Biomedicine (LCSB): Clinical & Experimental Neuroscience (Krüger Group)
http://hdl.handle.net/10993/17165

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