Reference : Therapeutic strategies for Parkinson's disease based on data derived from genetic res...
Scientific journals : Article
Life sciences : Genetics & genetic processes
http://hdl.handle.net/10993/17130
Therapeutic strategies for Parkinson's disease based on data derived from genetic research.
English
Riess, Olaf [> >]
Berg, Daniela [> >]
Krüger, Rejko mailto [University of Luxembourg > Faculty of Science, Technology and Communication (FSTC) > Life Science Research Unit]
Schulz, Jorg B. [> >]
2003
Journal of neurology
250 Suppl 1
I3-10
Yes (verified by ORBilu)
0340-5354
Germany
[en] Adjuvants, Immunologic ; Animals ; Antioxidants/therapeutic use ; Apoptosis/genetics/physiology ; Disease Models, Animal ; Genetics, Medical/methods ; Humans ; Immunotherapy, Active ; Iron/physiology ; Microglia/metabolism ; Mitochondria/metabolism ; Nerve Tissue Proteins/metabolism ; Parkinson Disease/genetics/metabolism/pathology/therapy ; Substantia Nigra/metabolism ; Synucleins ; alpha-Synuclein
[en] Following the identification of mutations in alpha-synuclein as the cause of some rare forms of familial Parkinson's disease (PD), genetic research has uncovered numerous gene loci of PD. Meanwhile, several neurodegenerative diseases have been shown to accumulate a-synuclein in neuronal and glial cells summarizing this group of diseases as synucleinopathies. All currently known gene defects causing PD alter the ubiquitin-proteasomal pathway of protein degradation. Identification of these disease mutations allows studying the functional consequences which lead to cellular dysfunction and cell death in cell culture and transgenic animal models, to identify therapeutic targets and to test potential protective strategies in these models.
Luxembourg Centre for Systems Biomedicine (LCSB): Clinical & Experimental Neuroscience (Krüger Group)
http://hdl.handle.net/10993/17130
10.1007/s00415-003-1101-3

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