Reference : Spectrum of phenotypes and genotypes in Parkinson's disease.
Scientific journals : Article
Life sciences : Genetics & genetic processes
http://hdl.handle.net/10993/17125
Spectrum of phenotypes and genotypes in Parkinson's disease.
English
Riess, Olaf [> >]
Krüger, Rejko mailto [University of Luxembourg > Faculty of Science, Technology and Communication (FSTC) > Life Science Research Unit]
Schulz, Jorg B. [> >]
2002
Journal of neurology
249 Suppl 3
III/15-20
Yes (verified by ORBilu)
0340-5354
Germany
[en] Chromosome Mapping ; Chromosomes/genetics ; Genotype ; Humans ; Ligases/genetics ; Mutation ; Nerve Tissue Proteins/genetics ; Nucleoside-Phosphate Kinase/genetics ; Parkinson Disease/genetics ; Phenotype ; Synucleins ; Ubiquitin-Protein Ligases
[en] The pathogenesis of Parkinsons disease (PD) is currently unknown. Environmental and genetic factors might contribute to the neurodegenerative process. Genetic mapping approaches in rare familial cases with autosomal recessive and autosomal dominant inheritance of PD suggest wide genetic heterogeneity of the disease. These gene loci in turn allow now a more specific clinical investigation of affected families to study the clinical heterogeneity of PD. The recent identification of mutations in three genes involved in protein degradation and aggregation in familial PD does now facilitate the deciphering of other genes involved in the pathogenesis of the disease.
Luxembourg Centre for Systems Biomedicine (LCSB): Clinical & Experimental Neuroscience (Krüger Group)
http://hdl.handle.net/10993/17125
10.1007/s00415-002-1303-2

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