Reference : Gene-wide analysis detects two new susceptibility genes for Alzheimer's disease.
Scientific journals : Article
Life sciences : Genetics & genetic processes
http://hdl.handle.net/10993/16997
Gene-wide analysis detects two new susceptibility genes for Alzheimer's disease.
English
Escott-Price, Valentina [> >]
Bellenguez, Celine [> >]
Wang, Li-San [> >]
Choi, Seung-Hoan [> >]
Harold, Denise [> >]
Jones, Lesley [> >]
Holmans, Peter [> >]
Gerrish, Amy [> >]
Vedernikov, Alexey [> >]
Richards, Alexander [> >]
DeStefano, Anita L. [> >]
Lambert, Jean-Charles [> >]
Ibrahim-Verbaas, Carla A. [> >]
Naj, Adam C. [> >]
Sims, Rebecca [> >]
Jun, Gyungah [> >]
Bis, Joshua C. [> >]
Beecham, Gary W. [> >]
Grenier-Boley, Benjamin [> >]
Russo, Giancarlo [> >]
Thornton-Wells, Tricia A. [> >]
Denning, Nicola [> >]
Smith, Albert V. [> >]
Chouraki, Vincent [> >]
Thomas, Charlene [> >]
Ikram, M. Arfan [> >]
Zelenika, Diana [> >]
Vardarajan, Badri N. [> >]
Kamatani, Yoichiro [> >]
Lin, Chiao-Feng [> >]
Schmidt, Helena [> >]
Kunkle, Brian [> >]
Dunstan, Melanie L. [> >]
Vronskaya, Maria [> >]
Johnson, Andrew D. [> >]
Ruiz, Agustin [> >]
Bihoreau, Marie-Therese [> >]
Reitz, Christiane [> >]
Pasquier, Florence [> >]
Hollingworth, Paul [> >]
Hanon, Olivier [> >]
Fitzpatrick, Annette L. [> >]
Buxbaum, Joseph D. [> >]
Campion, Dominique [> >]
Crane, Paul K. [> >]
Baldwin, Clinton [> >]
Becker, Tim [> >]
Gudnason, Vilmundur [> >]
Cruchaga, Carlos [> >]
Craig, David [> >]
Amin, Najaf [> >]
Berr, Claudine [> >]
Lopez, Oscar L. [> >]
De Jager, Philip L. [> >]
Deramecourt, Vincent [> >]
Johnston, Janet A. [> >]
Evans, Denis [> >]
Lovestone, Simon [> >]
Letenneur, Luc [> >]
Hernandez, Isabel [> >]
Rubinsztein, David C. [> >]
Eiriksdottir, Gudny [> >]
Sleegers, Kristel [> >]
Goate, Alison M. [> >]
Fievet, Nathalie [> >]
Huentelman, Matthew J. [> >]
Gill, Michael [> >]
Brown, Kristelle [> >]
Kamboh, M. Ilyas [> >]
Keller, Lina [> >]
Barberger-Gateau, Pascale [> >]
McGuinness, Bernadette [> >]
Larson, Eric B. [> >]
Myers, Amanda J. [> >]
Dufouil, Carole [> >]
Todd, Stephen [> >]
Wallon, David [> >]
Love, Seth [> >]
Rogaeva, Ekaterina [> >]
Gallacher, John [> >]
George-Hyslop, Peter St [> >]
Clarimon, Jordi [> >]
Lleo, Alberto [> >]
Bayer, Anthony [> >]
Tsuang, Debby W. [> >]
Yu, Lei [> >]
Tsolaki, Magda [> >]
Bossu, Paola [> >]
Spalletta, Gianfranco [> >]
Proitsi, Petra [> >]
Collinge, John [> >]
Sorbi, Sandro [> >]
Garcia, Florentino Sanchez [> >]
Fox, Nick C. [> >]
Hardy, John [> >]
Naranjo, Maria Candida Deniz [> >]
Bosco, Paolo [> >]
Clarke, Robert [> >]
Brayne, Carol [> >]
Galimberti, Daniela [> >]
Scarpini, Elio [> >]
Bonuccelli, Ubaldo [> >]
Mancuso, Michelangelo [> >]
Siciliano, Gabriele [> >]
Moebus, Susanne [> >]
Mecocci, Patrizia [> >]
Zompo, Maria Del [> >]
Maier, Wolfgang [> >]
Hampel, Harald [> >]
Pilotto, Alberto [> >]
Frank-Garcia, Ana [> >]
Panza, Francesco [> >]
Solfrizzi, Vincenzo [> >]
Caffarra, Paolo [> >]
Nacmias, Benedetta [> >]
Perry, William [> >]
Mayhaus, Manuel [> >]
Lannfelt, Lars [> >]
Hakonarson, Hakon [> >]
Pichler, Sabrina [> >]
Carrasquillo, Minerva M. [> >]
Ingelsson, Martin [> >]
Beekly, Duane [> >]
Alvarez, Victoria [> >]
Zou, Fanggeng [> >]
Valladares, Otto [> >]
Younkin, Steven G. [> >]
Coto, Eliecer [> >]
Hamilton-Nelson, Kara L. [> >]
Gu, Wei mailto [University Hospital, Saarland, Germany, > Department of Psychiatry]
Razquin, Cristina [> >]
Pastor, Pau [> >]
Mateo, Ignacio [> >]
Owen, Michael J. [> >]
Faber, Kelley M. [> >]
Jonsson, Palmi V. [> >]
Combarros, Onofre [> >]
O'Donovan, Michael C. [> >]
Cantwell, Laura B. [> >]
Soininen, Hilkka [> >]
Blacker, Deborah [> >]
Mead, Simon [> >]
Mosley, Thomas H. Jr [> >]
Bennett, David A. [> >]
Harris, Tamara B. [> >]
Fratiglioni, Laura [> >]
Holmes, Clive [> >]
de Bruijn, Renee F. A. G. [> >]
Passmore, Peter [> >]
Montine, Thomas J. [> >]
Bettens, Karolien [> >]
Rotter, Jerome I. [> >]
Brice, Alexis [> >]
Morgan, Kevin [> >]
Foroud, Tatiana M. [> >]
Kukull, Walter A. [> >]
Hannequin, Didier [> >]
Powell, John F. [> >]
Nalls, Michael A. [> >]
Ritchie, Karen [> >]
Lunetta, Kathryn L. [> >]
Kauwe, John S. K. [> >]
Boerwinkle, Eric [> >]
Riemenschneider, Matthias [> >]
Boada, Merce [> >]
Hiltunen, Mikko [> >]
Martin, Eden R. [> >]
Schmidt, Reinhold [> >]
Rujescu, Dan [> >]
Dartigues, Jean-Francois [> >]
Mayeux, Richard [> >]
Tzourio, Christophe [> >]
Hofman, Albert [> >]
Nothen, Markus M. [> >]
Graff, Caroline [> >]
Psaty, Bruce M. [> >]
Haines, Jonathan L. [> >]
Lathrop, Mark [> >]
Pericak-Vance, Margaret A. [> >]
Launer, Lenore J. [> >]
Van Broeckhoven, Christine [> >]
Farrer, Lindsay A. [> >]
van Duijn, Cornelia M. [> >]
Ramirez, Alfredo [> >]
Seshadri, Sudha [> >]
Schellenberg, Gerard D. [> >]
Amouyel, Philippe [> >]
Williams, Julie [> >]
2014
PloS one
9
6
e94661
Yes (verified by ORBilu)
International
1932-6203
1932-6203
United States
[en] BACKGROUND: Alzheimer's disease is a common debilitating dementia with known heritability, for which 20 late onset susceptibility loci have been identified, but more remain to be discovered. This study sought to identify new susceptibility genes, using an alternative gene-wide analytical approach which tests for patterns of association within genes, in the powerful genome-wide association dataset of the International Genomics of Alzheimer's Project Consortium, comprising over 7 m genotypes from 25,580 Alzheimer's cases and 48,466 controls. PRINCIPAL FINDINGS: In addition to earlier reported genes, we detected genome-wide significant loci on chromosomes 8 (TP53INP1, p = 1.4x10-6) and 14 (IGHV1-67 p = 7.9x10-8) which indexed novel susceptibility loci. SIGNIFICANCE: The additional genes identified in this study, have an array of functions previously implicated in Alzheimer's disease, including aspects of energy metabolism, protein degradation and the immune system and add further weight to these pathways as potential therapeutic targets in Alzheimer's disease.
Luxembourg Centre for Systems Biomedicine (LCSB): Bioinformatics Core (R. Schneider Group)
http://hdl.handle.net/10993/16997
10.1371/journal.pone.0094661

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