Reference : Comparative studies of transcriptional regulation mechanisms in a group of eight gamm...
Scientific journals : Article
Life sciences : Biochemistry, biophysics & molecular biology
http://hdl.handle.net/10993/16686
Comparative studies of transcriptional regulation mechanisms in a group of eight gamma-proteobacterial genomes.
English
Espinosa Angarica, Vladimir mailto [University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB) >]
Gonzalez, Abel D. [National Bioinformatics Center, Industria y San José, Capitolio Nacional, CP. 10200, Habana Vieja, Habana, Cuba]
Vasconcelos, Ana T. [National Laboratory for Scientific Computing, Avenue Getulio Vargas 333, Quitandinha, CEP 25651-075, Petropolis, Rio de Janeiro, Brazil]
Huerta, Araceli M. [Center of Genomics, UNAM, AP 565-A Cuernavaca, CP. 62100, Morelos, Mexico]
Collado-Vides, Julio [Center of Genomics, UNAM, AP 565-A Cuernavaca, CP. 62100, Morelos, Mexico]
2005
Journal of molecular biology
354
1
184-99
Yes (verified by ORBilu)
International
0022-2836
England
[en] TF-binding-sites prediction ; regulatory network ; regulon ; gamma-proteobacteria
[en] Experimental data on the Escherichia coli transcriptional regulation has enabled the construction of statistical models to predict new regulatory elements within its genome. Far less is known about the transcriptional regulatory elements in other gamma-proteobacteria with sequenced genomes, so it is of great interest to conduct comparative genomic studies oriented to extracting biologically relevant information about transcriptional regulation in these less studied organisms using the knowledge from E. coli. In this work, we use the information stored in the TRACTOR_DB database to conduct a comparative study on the mechanisms of transcriptional regulation in eight gamma-proteobacteria and 38 regulons. We assess the conservation of transcription factors binding specificity across all the eight genomes and show a correlation between the conservation of a regulatory site and the structure of the transcription unit it regulates. We also find a marked conservation of site-promoter distances across the eight organisms and a correspondence of the statistical significance of co-occurrence of pairs of transcription factor binding sites in the regulatory regions, which is probably related to a conserved architecture of higher-order regulatory complexes in the organisms studied. The results obtained in this study using the information on transcriptional regulation in E. coli enable us to conclude that not only transcription factor-binding sites are conserved across related species but also several of the transcriptional regulatory mechanisms previously identified in E. coli.
Researchers ; Students
http://hdl.handle.net/10993/16686
10.1016/j.jmb.2005.09.037
http://www.sciencedirect.com/science/article/pii/S0022283605011034

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