Reference : Comparing the MicroRNA Spectrum between Serum and Plasma
Scientific journals : Article
Life sciences : Multidisciplinary, general & others
http://hdl.handle.net/10993/16035
Comparing the MicroRNA Spectrum between Serum and Plasma
English
Wang, K. [Institute for Systems Biology - ISB]
Yuan, Y. [> >]
Cho, J. H. [> >]
McClarty, S. [> >]
Baxter, D. [> >]
Galas, David J. [University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB) > > ; Institute for Systems Biology - ISB]
31-Jul-2012
PLoS ONE
Public Library of Science
7
7
e41561
Yes (verified by ORBilu)
1932-6203
San Franscisco
CA
[en] MicroRNAs (miRNAs) are small, non-coding RNAs that regulate various biological processes, primarily through interaction with messenger RNAs. The levels of specific, circulating miRNAs in blood have been shown to associate with various pathological conditions including cancers. These miRNAs have great potential as biomarkers for various pathophysiological conditions. In this study we focused on different sample types’ effects on the spectrum of circulating miRNA in blood. Using serum and corresponding plasma samples from the same individuals, we observed higher miRNA concentrations in serum samples compared to the corresponding plasma samples. The difference between serum and plasma miRNA concentration showed some associations with miRNA from platelets, which may indicate that the coagulation process may affect the spectrum of extracellular miRNA in blood. Several miRNAs also showed platform dependent variations in measurements. Our results suggest that there are a number of factors that might affect the measurement of circulating miRNA concentration. Caution must be taken when comparing miRNA data generated from different sample types or measurement platforms
Luxembourg Centre for Systems Biomedicine (LCSB): Experimental Neurobiology (Balling Group)
http://hdl.handle.net/10993/16035
10.1371/journal.pone.0041561

File(s) associated to this reference

Fulltext file(s):

FileCommentaryVersionSizeAccess
Open access
Galas.pdfPublisher postprint359.44 kBView/Open

Bookmark and Share SFX Query

All documents in ORBilu are protected by a user license.