Reference : The battle of two genomes: genetics of bacterial host/pathogen interactions in mice.
Scientific journals : Article
Life sciences : Genetics & genetic processes
http://hdl.handle.net/10993/1563
The battle of two genomes: genetics of bacterial host/pathogen interactions in mice.
English
Lengeling, A. [> >]
Pfeffer, K. [> >]
Balling, Rudi mailto []
2001
Mammalian Genome : Official Journal of the International Mammalian Genome Society
12
4
261-71
Yes (verified by ORBilu)
0938-8990
1432-1777
United States
[en] Animals ; Apoptosis ; Bacteria/genetics/pathogenicity ; Bacterial Infections/genetics/microbiology ; Disease Models, Animal ; Gene Expression ; Genes, Bacterial ; Genetic Predisposition to Disease ; Genome ; Humans ; Immunity, Innate ; Mice ; Mice, Knockout ; Quantitative Trait, Heritable ; Virulence/genetics
[en] Genetic factors strongly determine the outcome of infectious diseases caused by various pathogens. The molecular mechanisms of resistance and susceptibility in humans, however, remains largely unknown. Complex interactions of multiple genes that control the host response to a pathogen further complicate the picture. Animal models have a tremendous potential to dissect the complex genetic system of host-pathogen interaction into single components. This is particularly true for the mouse, which will continue to develop into an invaluable tool in the identification and cloning of host resistance genes. Three main approaches have been taken to establish mouse models for human infectious diseases: 1) Production of mouse mutants by gene targeting; 2) positional cloning of host-resistance genes in mutant mice; and 3) mapping and characterization of quantitative trait loci (QTL) controlling the complex aspects of host-pathogen interactions. The contribution of all three methods to the understanding of infectious diseases in humans will be reviewed in this work, with a special emphasis on the studies of resistance/susceptibility mechanism in bacterial infections.
http://hdl.handle.net/10993/1563
10.1007/s003350040001

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